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Recombinant Human EIF2S1 cell lysate

Cat.No. : EIF2S1-542HCL
  • Specification
  • Gene Information
  • Related Products
Description : The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [ Homo sapiens ]
Official Symbol : EIF2S1
Synonyms : EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2, eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); eukaryotic translation initiation factor 2 subunit 1; EIF 2alpha; EIF2A; eIF-2-alpha; eukaryotic translation initiation factor 2 subunit alpha; EIF2; EIF-2; EIF-2A; EIF-2alpha;
Gene ID : 1965
mRNA Refseq : NM_004094
Protein Refseq : NP_004085
MIM : 603907
UniProt ID : P05198
Chromosome Location : 14q21.3
Pathway : Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem; GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem;
Function : RNA binding; protein binding; ribosome binding; translation initiation factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is the expression of EIF2S1 regulated? 10/27/2022

The expression of EIF2S1 gene is affected by a variety of factors, including nutrients, growth factors, hormones, stress status, etc. Its expression regulation mainly occurs at the transcriptional level and the post-transcriptional level.

How does the EIF2S1 gene interact with RNA polymerase? 08/31/2021

The protein encoded by the EIF2S1 gene can bind to RNA polymerase to form a translation initiation complex, thus participating in the translation process of mRNA.

What is the main function of the EIF2S1 gene in cells? 08/21/2021

The protein encoded by the EIF2S1 gene is a subunit of the translation initiation factor eIF-2, which is involved in the initiation of the protein translation process in the cell.

What is the effect of EIF2S1 gene on apoptosis? 01/19/2021

Studies have shown that EIF2S1 gene may play an important role in the process of apoptosis, but its specific mechanism of action still needs further research.

What role does the EIF2S1 gene play in the cell cycle and cell differentiation? 07/21/2020

The EIF2S1 gene lays an important role in the cell cycle and cell differentiation, and is involved in the regulation of cell growth, division and differentiation.

Are there different subtypes or variants of the EIF2S1 gene? 01/08/2020

Yes, there are different isoforms or variants of the EIF2S1 gene, and these variants may have different functions and expression patterns.

Customer Reviews (3)

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Reviews
09/17/2023

    EIF2S1 was used to find high purity and no significant impurities.

    08/23/2023

      It was observed that its expression level was high, which was able to meet the needs of the experiment.

      04/01/2021

        Its stability is good, and there is no obvious change in the process of storage and transportation.

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