Recombinant Human EIF2S1 cell lysate
Cat.No. : | EIF2S1-542HCL |
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- Gene Information
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Description : | The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [ Homo sapiens ] |
Official Symbol : | EIF2S1 |
Synonyms : | EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; EIF2, eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD ); eukaryotic translation initiation factor 2 subunit 1; EIF 2alpha; EIF2A; eIF-2-alpha; eukaryotic translation initiation factor 2 subunit alpha; EIF2; EIF-2; EIF-2A; EIF-2alpha; |
Gene ID : | 1965 |
mRNA Refseq : | NM_004094 |
Protein Refseq : | NP_004085 |
MIM : | 603907 |
UniProt ID : | P05198 |
Chromosome Location : | 14q21.3 |
Pathway : | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Eukaryotic Translation Initiation, organism-specific biosystem; Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem; GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem; |
Function : | RNA binding; protein binding; ribosome binding; translation initiation factor activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe expression of EIF2S1 gene is affected by a variety of factors, including nutrients, growth factors, hormones, stress status, etc. Its expression regulation mainly occurs at the transcriptional level and the post-transcriptional level.
The protein encoded by the EIF2S1 gene can bind to RNA polymerase to form a translation initiation complex, thus participating in the translation process of mRNA.
The protein encoded by the EIF2S1 gene is a subunit of the translation initiation factor eIF-2, which is involved in the initiation of the protein translation process in the cell.
Studies have shown that EIF2S1 gene may play an important role in the process of apoptosis, but its specific mechanism of action still needs further research.
The EIF2S1 gene lays an important role in the cell cycle and cell differentiation, and is involved in the regulation of cell growth, division and differentiation.
Yes, there are different isoforms or variants of the EIF2S1 gene, and these variants may have different functions and expression patterns.
Customer Reviews (3)
Write a reviewEIF2S1 was used to find high purity and no significant impurities.
It was observed that its expression level was high, which was able to meet the needs of the experiment.
Its stability is good, and there is no obvious change in the process of storage and transportation.
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