Recombinant Human EIF4G1 cell lysate
Cat.No. : | EIF4G1-545HCL |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 [ Homo sapiens ] |
Official Symbol : | EIF4G1 |
Synonyms : | EIF4G1; eukaryotic translation initiation factor 4 gamma, 1; EIF4F, EIF4G; eukaryotic translation initiation factor 4 gamma 1; p220; EIF4-gamma; eIF-4-gamma 1; eucaryotic translation initiation factor 4G; P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; DKFZp686A1451; |
Gene ID : | 1981 |
mRNA Refseq : | NM_001194946 |
Protein Refseq : | NP_001181875 |
MIM : | 600495 |
UniProt ID : | Q04637 |
Chromosome Location : | 3q27-qter |
Pathway : | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem; |
Function : | protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity; |
Products Types
◆ Recombinant Protein | ||
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EIF4G1-1387H | Recombinant Human EIF4G1 Protein (1250-1599 aa), His-tagged | +Inquiry |
Eif4g1-2789M | Recombinant Mouse Eif4g1 Protein, Myc/DDK-tagged | +Inquiry |
EIF4G1-830H | Recombinant Human EIF4G1 Protein, His (Fc)-Avi-tagged | +Inquiry |
EIF4G1-02H | Recombinant Human EIF4G1 protein, Myc/DDK-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionSome current findings suggest that EIF4G1 may be a potential target for cancer treatment and other disease treatments. However, research in this field is still relatively early, and more experimental and clinical validation is still needed.
Mutations in the EIF4G1 protein may affect the assembly and functioning of its translation complex, thereby affecting its biological function in cell physiology and disease processes.
The protein is involved in important cell biological processes such as the formation of translational initiation complexes, mRNA translation, transcriptional regulation, and cell signaling.
Research on EIF4G1 protein versus drug therapy is still in its infancy, but there are already many studies that show that EIF4G1 protein is very important for drug treatment.
Promotes cancer cell growth, proliferation, and deterioration by facilitating the assembly of transcriptional and translational initiation complexes. Therefore, the researchers now believe that EIF4G1 may be a potential target for cancer treatment.
EIF4G1 plays an important role in the occurrence and progression of various diseases such as cancer, neurodegenerative diseases and inflammation, and its application in the treatment of these diseases is currently being actively explored.
Customer Reviews (3)
Write a reviewThe activity is strong, and the protein requires only a small amount to achieve the desired effect compared to other proteins.
Very suitable for biosensors, high sensitivity.
It performs very well in terms of recombinant expression.
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