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Recombinant Human GATA1 cell lysate

Cat.No. : GATA1-689HCL
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : GATA1 GATA binding protein 1 (globin transcription factor 1) [ Homo sapiens ]
Official Symbol : GATA1
Synonyms : GATA1; GATA binding protein 1 (globin transcription factor 1); GATA binding protein 1 (globin transcription factor 1) , GF1; erythroid transcription factor; ERYF1; GATA 1; NFE1; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; globin transcription factor 1; erythroid transcription factor 1; GF1; GF-1; XLTT; GATA-1;
Gene ID : 2623
mRNA Refseq : NM_002049
Protein Refseq : NP_002040
MIM : 305371
UniProt ID : P15976
Chromosome Location : Xp11.23
Pathway : C-MYB transcription factor network, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem;
Function : C2H2 zinc finger domain binding; DNA binding; DNA binding, bending; RNA polymerase II core promoter proximal region sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; chromatin binding; enhancer sequence-specific DNA binding; metal ion binding; p53 binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region sequence-specific DNA binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is GATA1 involved in the regulation of immune responses? 03/21/2021

GATA1 primarily functions in hematopoiesis and is not directly involved in the regulation of immune responses. Its role is more specific to blood cell development.

Are there clinical conditions associated with GATA1 mutations? 10/23/2017

Yes, mutations in the GATA1 gene are linked to various hematological disorders, including Diamond-Blackfan anemia and transient myeloproliferative disorder in Down syndrome.

How does understanding GATA1 help in the prognosis of hematological disorders? 04/05/2017

Knowledge of GATA1 mutations can contribute to a more accurate prognosis, guiding healthcare professionals in developing appropriate treatment plans and monitoring strategies.

Can GATA1 mutations lead to leukemia? 01/14/2017

Yes, mutations in the GATA1 gene have been implicated in the development of acute megakaryoblastic leukemia, particularly in children with Down syndrome.

How does GATA1 contribute to normal blood cell function? 01/05/2017

GATA1 controls the expression of genes necessary for normal blood cell development, ensuring proper function and regulation of erythrocytes and platelets.

Customer Reviews (3)

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Reviews
05/01/2021

    Whether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.

    12/25/2018

      The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

      07/24/2017

        In addition to its scientific merits, the manufacturer of GATA1 protein stands out for its outstanding technical support.

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