Recombinant Human STRADA cell lysate

• Cat.No.: STRADA-1041HCL

Specification

• Description: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: STRADA STE20-related kinase adaptor alpha [ Homo sapiens ]
• Official Symbol: STRADA
• Synonyms: STRADA; STE20-related kinase adaptor alpha; STE20-related kinase adapter protein alpha; LYK5; NY BR 96; STE20 like pseudokinase; Stlk; STRAD; STRAD alpha; protein kinase LYK5; STE20-like pseudokinase; serologically defined breast cancer antigen NY-BR-96; PMSE; NY-BR-96; FLJ90524
• Gene ID: 92335
• mRNA Refseq: NM_001003786
• Protein Refseq: NP_001003786
• MIM: 608626
• UniProt ID: Q7RTN6
• Chromosome Location: 17q23.3
• Pathway: Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin receptor signalling cascade, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; PI3K Cascade, organism-specific biosystem; PKB-mediated events, organism-specific biosystem
• Function: ATP binding; kinase binding; nucleotide binding; protein binding; protein kinase activator activity; NOT protein kinase activity; contributes_to protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity; transferase activity, transferring phosphorus-containing groups