Recombinant Human NRCAM cell lysate

• Cat.No.: NRCAM-1220HCL

Specification

• Description: Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: NRCAM neuronal cell adhesion molecule [ Homo sapiens ]
• Official Symbol: NRCAM
• Synonyms: NRCAM; neuronal cell adhesion molecule; Bravo; KIAA0343; NgCAM related cell adhesion molecule; neuronal surface protein Bravo; NgCAM-related cell adhesion molecule; MGC138845; MGC138846
• Gene ID: 4897
• mRNA Refseq: NM_001037132
• Protein Refseq: NP_001032209
• MIM: 601581
• UniProt ID: Q92823
• Chromosome Location: 7q31
• Pathway: Axon guidance, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Developmental Biology, organism-specific biosystem; Interaction between L1 and Ankyrins, organism-specific biosystem; L1CAM interactions, organism-specific biosystem; Neurofascin interactions, organism-specific biosystem
• Function: ankyrin binding