Recombinant Human PABPC4 cell lysate

• Cat.No.: PABPC4-1271HCL

Specification

• Description: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) [ Homo sapiens ]
• Official Symbol: PABPC4
• Synonyms: PABPC4; poly(A) binding protein, cytoplasmic 4 (inducible form); polyadenylate-binding protein 4; APP 1; iPABP; PABP-4; poly(A)-binding protein 4; activated-platelet protein 1; inducible poly(A)-binding protein; APP1; APP-1; PABP4; FLJ43938
• Gene ID: 8761
• mRNA Refseq: NM_001135653
• Protein Refseq: NP_001129125
• MIM: 603407
• UniProt ID: Q13310
• Chromosome Location: 1p34.2
• Pathway: RNA degradation, organism-specific biosystem; RNA degradation, conserved biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem; mRNA surveillance pathway, organism-specific biosystem; mRNA surveillance pathway, conserved biosystem
• Function: RNA binding; nucleotide binding; poly(A) RNA binding; NOT poly(C) RNA binding; poly(U) RNA binding; protein binding

Reviews

07/10/2019

Dependable partner, a cornerstone of our research.

12/12/2018

Efficient and precise, supports our research endeavors.

08/11/2017

Key to our research success, highly recommended.

Q&As

How does PABPC4 interact with other RNA-binding proteins?

PABPC4 works in conjunction with other RNA-binding proteins to coordinate mRNA regulation and translation.

What role does PABPC4 play in protein synthesis?

PABPC4 plays a significant role in facilitating protein synthesis by stabilizing mRNA during translation.

What is the primary role of PABPC4 in mRNA regulation?

PABPC4, a poly(A) binding protein, is crucial for regulating mRNA stability and translation in cells.

How do genetic variations in PABPC4 affect gene expression?

Genetic mutations in PABPC4 can lead to disrupted mRNA processing and altered gene expression.

What is the impact of altered PABPC4 activity on cellular processes?

Altered PABPC4 activity can impact various cellular functions, including protein production and cell signaling.

How does PABPC4 contribute to mRNA stability?

It enhances mRNA stability by binding to the poly(A) tail, protecting mRNA from degradation.

What potential therapeutic applications arise from targeting PABPC4 in RNA-related disorders?

Targeting PABPC4 could provide new treatment strategies for diseases involving mRNA processing abnormalities.