Recombinant Human RGS14 cell lysate

• Cat.No.: RGS14-1502HCL

Specification

• Description: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: RGS14 regulator of G-protein signaling 14 [ Homo sapiens ]
• Official Symbol: RGS14
• Synonyms: RGS14; regulator of G-protein signaling 14; regulator of G protein signalling 14; regulator of G-protein signalling 14
• Gene ID: 10636
• mRNA Refseq: NM_006480
• Protein Refseq: NP_006471
• MIM: 602513
• UniProt ID: O43566
• Chromosome Location: 5q35.3
• Pathway: Calcium Regulation in the Cardiac Cell, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem
• Function: GDP-dissociation inhibitor activity; GTPase activating protein binding; GTPase activator activity; GTPase activator activity; microtubule binding; protein kinase binding; receptor signaling complex scaffold activity; receptor signaling protein activity