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Recombinant Human FZD5, Fc-tagged

Cat.No.: FZD5-167H
Product Overview: Recombinant Human FZD5 /Frizzled-5 Protein, with C-Fc Tag (rh FZD5 / Frizzled-5 Fc Chimera) Ala 27 - Pro 167 (Accession # Q13467) was produced in human 293 cells (HEK293).
Description: Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
Source: HEK293
Species: Human
Tag: Fc
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: rh FZD5 / Frizzled-5 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 42.6 kDa. The predicted N-terminus is Ala 27. DTT-reduced Protein migrates as 55-60 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh FZD5 / Frizzled-5 Fc Chimera by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name: FZD5 frizzled family receptor 5 [ Homo sapiens ]
Official Symbol: FZD5
Synonyms: FZD5; frizzled family receptor 5; C2orf31, chromosome 2 open reading frame 31 , frizzled (Drosophila) homolog 5 , frizzled 5, seven transmembrane spanning receptor , frizzled homolog 5 (Drosophila); frizzled-5; DKFZP434E2135; HFZ5; fz-5; fzE5; Wnt receptor; seven-transmembrane receptor frizzled-5; frizzled 5, seven transmembrane spanning receptor; C2orf31; MGC129692; DKFZp434E2135;
Gene ID: 7855
mRNA Refseq: NM_003468
Protein Refseq: NP_003459
MIM: 601723
UniProt ID: Q13467
Chromosome Location: 2q33.3
Pathway: Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function: G-protein coupled receptor activity; PDZ domain binding; Wnt-activated receptor activity; Wnt-activated receptor activity; Wnt-protein binding; protein binding; protein kinase binding; receptor activity; signal transducer activity;

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