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Recombinant Human EFNA4, Fc-tagged

Cat.No.: EFNA4-177H
Product Overview: Recombinant Human Ephrin A4 /EFNA4 Protein,C-Fc Tag (rh Ephrin A4 /EFNA4 Fc Chimera) Leu 26 - Gly 171 (Accession # AAI07484) was produced in human 293 cells (HEK293).
Description: Ephrin-A4 (EFNA4) is also known as EPH-related receptor tyrosine kinase ligand 4 (LERK4), EPLG4, which belongs to the ephrin family. EFNA4 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA4 is cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA4 may play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Source: HEK293
Species: Human
Tag: Fc
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: rh Ephrin A4 /EFNA4 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 43 kDa. The predicted N-terminus is Leu 26. DTT-reduced Protein migrates as 48 kDa and 34 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh Ephrin A4 /EFNA4 Fc Chimera by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name: EFNA4 ephrin-A4 [ Homo sapiens ]
Official Symbol: EFNA4
Synonyms: EFNA4; ephrin-A4; EPLG4; LERK4; LERK-4; ligand of eph-related kinase 4; eph-related receptor tyrosine kinase ligand 4; EFL4; FLJ57652; MGC125826;
Gene ID: 1945
mRNA Refseq: NM_005227
Protein Refseq: NP_005218
MIM: 601380
UniProt ID: P52798
Chromosome Location: 1q21-q22
Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem;
Function: ephrin receptor binding; transmembrane-ephrin receptor activity;

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