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Recombinant Cynomolgus CD3E&CD3D, His-Fc&Flag-Fc tagged

Cat.No. : CD3E&CD3D-220C
Product Overview : Recombinant Cynomolgus CD3E & CD3D heterodimer protein (Cynomolgus CD3E & CD3D heterodimer) Gln 22 - Asp 117 (CD3E,Q95LI5) & Phe 22 - Ala 105 (CD3D,Q95LI8) was produced in human 293 cells (HEK293).
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Description : T-cell surface glycoprotein CD3 delta & CD3 epsilon chain, also known as CD3D & CD3E or CD3D&CD3E respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
Source : HEK293
Species : Cynomolgus
Tag : His-Fc&Flag-Fc
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass : The heterodimer Cynomolgus CD3E & CD3D heterodimer Fc Chimera is produced by co-expression of CD3E and CD3D, has a calculated MW of 38.3 kDa (CD3E) and 37.5 kDa (CD3D). Subunit CD3E is fused with his-tagged human IgG1 Fc fragment at the C-terminus and sub
Endotoxin : Less than 1.0 EU per μg of the Cynomolgus CD3E & CD3D heterodimer Fc Chimera by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution : See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name : CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : CD3E
Synonyms : FLJ18683, T3E, TCRE, CD3E, CD3-epsilon, CD3 epsilon, T-cell surface glycoprotein CD3 epsilon chain, CD3 epsilon FN18+, CD3 epsilon FN18-
Gene ID : 102133065
mRNA Refseq : NM_001283615.1
Protein Refseq : NP_001270544.1
UniProt ID : Mfa.6117
Pathway : Chagas disease (American trypanosomiasis), organism-specific biosystem; HTLV-I infection, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Measles, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can CD3E be used to assess the effectiveness of cancer immunotherapies? 04/07/2021

Yes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.

Are there any CD3E-targeted therapies? 06/01/2017

There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.

Are there any ongoing clinical trials involving CD3E? 12/20/2016

There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.

Can CD3E levels be used to monitor the progression of HIV? 08/27/2016

Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.

How is CD3E used in allergy diagnostics? 06/22/2016

CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.

Customer Reviews (3)

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Reviews
03/22/2023

    Manufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.

    09/12/2021

      bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.

      06/17/2018

        Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.

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