Recombinant Human MCM3, GST-tagged
Cat.No. : | MCM3-23H |
Product Overview : | Recombinant Human MCM3( 699 a.a. - 808 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 37.84 kDa |
AA Sequence : | AKDGDSYDPYDFSDTEEEMPQVHTP KTADSQETKESQKVELSESRLKAFK VALLDVFREAHAQSIGMNRLTESIN RDSEEPFSSVEIQAALSKMQDDNQV MVSEGIIFLI |
Applications : | ELISA; WB-Re; AP; Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MCM3 minichromosome maintenance complex component 3 [ Homo sapiens ] |
Official Symbol : | MCM3 |
Synonyms : | MCM3; minichromosome maintenance complex component 3; HCC5; P1.h; RLFB; P1-MCM3; DNA replication licensing factor MCM3; p102; RLF subunit beta; hRlf beta subunit; DNA replication factor MCM3; cervical cancer proto-oncogene 5; minichromosome maintenance deficient 3; replication licensing factor, beta subunit; replication licensing factor, beta subunit; DNA polymerase alpha holoenzyme-associated protein P1; NP_001257401.1; EC 3.6.4.12; NP_002379.3 |
Gene ID : | 4172 |
mRNA Refseq : | NM_002388 |
Protein Refseq : | NP_002379 |
MIM : | 602693 |
UniProt ID : | P25205 |
Chromosome Location : | 6p12 |
Pathway : | Activation of ATR in response to replication sress; DNA Replication; E2F transcription factor network; G2/M Checkpoints |
Function : | ATP binding; DNA binding; DNA helicase activity; protein binding |
Products Types
◆ Recombinant Protein | ||
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MCM3-5411M | Recombinant Mouse MCM3 Protein, His (Fc)-Avi-tagged | +Inquiry |
MCM3-1382H | Recombinant Human MCM3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mcm3-3996M | Recombinant Mouse Mcm3 Protein, Myc/DDK-tagged | +Inquiry |
MCM3-1563C | Recombinant Chicken MCM3 | +Inquiry |
◆ Lysates | ||
MCM3-4419HCL | Recombinant Human MCM3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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