"PLCG1" Related Products


Recombinant Human PLCG1, MYC/DDK-tagged

Cat.No.: PLCG1-17H
Product Overview: Recombinant Human PLCG1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Source: HEK293 cells
Species: Human
Molecular Mass: 148.5 kDa
Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name: PLCG1 phospholipase C, gamma 1 [ Homo sapiens ]
Official Symbol: PLCG1
Synonyms: PLCG1; PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; phospholipase C, gamma 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; NP_002651.2; EC
Gene ID: 5335
mRNA Refseq: NM_002660
Protein Refseq: NP_002651
MIM: 172420
UniProt ID: P19174
Chromosome Location: 20q12-q13.1
Pathway: Adaptive Immune System; Antiviral mechanism by IFN-stimulated genes; Calcium signaling pathway
Function: calcium ion binding; glutamate receptor binding; phosphatidylinositol phospholipase C activity

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