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Recombinant Human NGF

Cat.No.: NGF-54H
Product Overview: Recombinant Human Nerve Growth Factor was expressed in yeast.
Description: Nerve growth factor (NGF) is a naturally occurring molecule in the body which stimulates the growth and differentiation of the sympathetic and certain sensory nerves. NGF is a protein that consists of 3 types of polypeptide chains -- alpha, beta and gamma -- that interact to form the protein. The NGF beta chain (NGFB) is solely responsible for the nerve growth stimulating activity of NGF. The NGFB gene is in chromosome band 1p22. An ointment containing NGF has been reported to help heal bedsores (decubiti).This complex contains 2 identical 118-amino acid beta-chains, which are solely responsible for nerve growth stimulating activity of NGF. Human DNA fragments coding for NGF were identified by Zabel et al. (1984) using a mouse submaxillary cDNA probe.
Source: Yeast
Species: Human
Form: Lyophilized from sterile 20mM PB,240mM NaCl,PH6.0.
Molecular Mass: 28.3kDa
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >95 % as determined by SDS-PAGE
Applications: Western blotting, ELISA
Storage: Store it under sterile conditions at -20℃ to -103℃ upon receiving.Recommend to aliquot the protein into smaller quantities for optimal storage.
Gene Name: NGF nerve growth factor (beta polypeptide) [ Homo sapiens ]
Official Symbol: NGF
Synonyms: NGF; nerve growth factor (beta polypeptide); NGFB; beta-nerve growth factor; nerve growth factor, beta subunit; HSAN5; Beta-NGF; MGC161426; MGC161428;
Gene ID: 4803
mRNA Refseq: NM_002506
Protein Refseq: NP_002497
MIM: 162030
UniProt ID: P01138
Chromosome Location: 1p13.1
Pathway: ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem;
Function: growth factor activity; nerve growth factor receptor binding; receptor signaling protein activity;

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