Recombinant Human CD14, His-tagged

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Recombinant Human CD14, His-tagged

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Cat.No. : CD14-28H
Product Overview : CD14 Human Recombinant produced by mammalian expression system in human cells is a single polypeptide chain containing 341 amino acids (20-352). CD14 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Description : The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
Source : HEK293 cells.
Species : Human
Tag : His
Form : Sterile Filtered White lyophilized (freeze-dried) powder. CD14 was lyophilized from a 0.2 μM filtered solution of 20mM PB and 150mM NaCl, PH 7.4.
AA Sequence : TTPEPCELDD EDFRCVCNFS EPQPDWSEAF QCVSAVEVEI HAGGLNLEPF LKRVDADADP RQYADTVKAL RVRRLTVGAA QVPAQLLVGA LRVLAYSRLK ELTLEDLKIT GTMPPLPLEA TGLALSSLRL RNVSWATGRS WLAELQQWLK PGLKVLSIAQ AHSPAFSCEQ VRAFPALTSL DLSDNPGLGE RGLMAALCPH KFPAIQNLAL RNTGMETPTG VCAALAAAGV QPHSLDLSHN SLRATVNPSA PRCMWSSALN SLNLSFAGLE QVPKGLPAKL RVLDLSCNRL NRAPQPDELP EVDNLTLDGN PFLVPGTALP HEGSMNSGVV PACVDHHHHH H
Purity : Greater than 95% as determined by SDS-PAGE.
Stability : Lyophilized CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD14 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized CD14 in 1xPBS to a concentration no less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Gene Name : CD14 CD14 molecule [ Homo sapiens (human) ]
Official Symbol : CD14
Synonyms : CD14; CD14 molecule; CD14 antigen; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
Gene ID : 929
mRNA Refseq : NM_000591
Protein Refseq : NP_000582
MIM : 158120
UniProt ID : P08571
Chromosome Location : 5q31.1
Pathway : Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Hematopoietic cell lineage; IKK complex recruitment mediated by RIP1
Function : lipopolysaccharide binding; lipoteichoic acid binding; peptidoglycan receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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