Recombinant Human TGFB3, His-tagged
Cat.No. : | TGFB3-12H |
Product Overview : | Recombinant human TGFB3, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Liquid, In 20mM Tris-HCl (pH8.0) containing 10% glycerol |
Molecular Mass : | 47.2kDa (412aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHSTVLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS |
Purity : | > 85% by SDS - PAGE |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5mg/ml (determined by Bradford assay) |
Gene Name : | TGFB3 transforming growth factor, beta 3 [ Homo sapiens ] |
Official Symbol : | TGFB3 |
Synonyms : | TGFB3; Transforming Growth Factor-beta3; ARVD; FLJ16571; TGF-beta3; transforming growth factor, beta 3 |
Gene ID : | 7043 |
mRNA Refseq : | NM_003239 |
Protein Refseq : | NP_003230 |
MIM : | 190230 |
UniProt ID : | P10600 |
Chromosome Location : | 14q24 |
Pathway : | ALK1 signaling events; Chagas disease (American trypanosomiasis); Chronic myeloid leukemia |
Function : | growth factor activity; identical protein binding; contributes_to protein binding |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionCurrently, researchers are exploring treatments that target TGFB3. Several drugs and antibodies have shown potential efficacy against TGFB3 and are being used in clinical trials for the treatment of the disease.
TGFB3 can regulate cell proliferation by activating multiple signaling pathways, such as the Smad signaling pathway and non-Smad signaling pathway. It can promote the progression of the cell cycle or inhibit cell proliferation, depending on the cell type and context.
TGFB3 protein can be used as a biomarker to assist the clinical diagnosis of a variety of diseases, such as congenital developmental abnormalities, inflammatory diseases and fibrotic diseases. Measuring TGFB3 protein levels can provide an indicator of early diagnosis and prognostic assessment of disease.
Mutations in TGFB3 have been found to be associated with inherited connective tissue diseases such as Loeys-Dietz syndrome and Marfan syndrome.
In pulmonary fibrosis, the expression of TGFB3 is elevated and is involved in the development of pulmonary fibrosis. Due to its important role in the pathological process, inhibition of the TGFB3 signaling pathway may be a potential strategy for the treatment of pulmonary fibrosis.
TGFB3 plays an important regulatory role in the immune system. It can influence the immune response through the proliferation, differentiation, and functional regulation of immune cells.
Customer Reviews (3)
Write a reviewReproducibility is very good, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of reproducibility.
Their recombinant proteins are very soluble and can be easily dissolved in various buffers.
Catalytic activity of this protein is very high, which can greatly reduce the time and energy required for chemical reactions and has high economic value.
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