Recombinant Human NEFL, GST-tagged
Cat.No. : | NEFL-12H |
Product Overview : | Recombinant Human NEFL(1 a.a. - 543 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
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Description : | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 87.9 kDa |
AA Sequence : | MSSFSYEPYYSTSYKRRYVETPRVH ISSVRSGYSTARSAYSSYSAPVSSS LSVRRSYSSSSGSLMPSLENLDLSQ VAAISNDLKSIRTQEKAQLQDLNDR FASFIERVHELEQQNKVLEAELLVL RQKHSEPSRFRALYEQEIRDLRLAA EDATNEKQALQGEREGLEETLRNLQ ARYEEEVLSREDAEGRLMEARKGAD EAALARAELEKRIDSLMDEISFLKK VHEEEIAELQAQIQYAQISVEMDVT KPDLSAALKDIRAQYEKLAAKNMQN AEEWFKSRFTVLTESAAKNTDAVRA AKDEVSESRRLLKAKTLEIEACRGM NEALEKQLQELEDKQNADISAMQDT INKLENELRTTKSEMARYLKEYQDL LNVKMALDIEIAAYRKLLEGEETRL SFTSVGSITSGYSQSSQVFGRSAYG GLQTSSYLMSTRSFPSYYTSHVQEE QIEVEETIEAAKAEEAKDEPPSEGE AEEEEKDKEEAEEEEAAEEEEAAKE ESEEAKEEEEGGEGEEGEETKEAEE EEKKVEGAGEEQAAKKKD |
Applications : | ELISA; WB-Re; AP; Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | NEFL neurofilament, light polypeptide [ Homo sapiens ] |
Official Symbol : | NEFL |
Synonyms : | NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig |
Gene ID : | 4747 |
mRNA Refseq : | NM_006158 |
Protein Refseq : | NP_006149 |
MIM : | 162280 |
UniProt ID : | P07196 |
Chromosome Location : | 8p21 |
Pathway : | Activation of NMDA receptor upon glutamate binding and postsynaptic events; Amyotrophic lateral sclerosis (ALS); CREB phosphorylation through the activation of Ras |
Function : | identical protein binding; phospholipase binding; protein C-terminus binding |
Products Types
◆ Native Protein | ||
NFL-01P | Native Pig NFL Protein (549 AA) | +Inquiry |
NEFL-181B | Native bovine NEFL | +Inquiry |
◆ Lysates | ||
NEFL-3884HCL | Recombinant Human NEFL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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