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Recombinant Human NEFL, GST-tagged
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Cat.No. : | NEFL-12H |
Product Overview : | Recombinant Human NEFL(1 a.a. - 543 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
Description : | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 87.9 kDa |
AA Sequence : | MSSFSYEPYY STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS LSVRRSYSSS SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR FASFIERVHE LEQQNKVLEA ELLVLRQKHS EPSRFRALYE QEIRDLRLAA EDATNEKQAL QGEREGLEET LRNLQARYEE EVLSREDAEG RLMEARKGAD EAALARAELE KRIDSLMDEI SFLKKVHEEE IAELQAQIQY AQISVEMDVT KPDLSAALKD IRAQYEKLAA KNMQNAEEWF KSRFTVLTES AAKNTDAVRA AKDEVSESRR LLKAKTLEIE ACRGMNEALE KQLQELEDKQ NADISAMQDT INKLENELRT TKSEMARYLK EYQDLLNVKM ALDIEIAAYR KLLEGEETRL SFTSVGSITS GYSQSSQVFG RSAYGGLQTS SYLMSTRSFP SYYTSHVQEE QIEVEETIEA AKAEEAKDEP PSEGEAEEEE KDKEEAEEEE AAEEEEAAKE ESEEAKEEEE GGEGEEGEET KEAEEEEKKV EGAGEEQAAK KKD |
Applications : | ELISA; WB-Re; AP; Array |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | NEFL neurofilament, light polypeptide [ Homo sapiens ] |
Official Symbol : | NEFL |
Synonyms : | NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weig |
Gene ID : | 4747 |
mRNA Refseq : | NM_006158 |
Protein Refseq : | NP_006149 |
MIM : | 162280 |
UniProt ID : | P07196 |
Chromosome Location : | 8p21 |
Pathway : | Activation of NMDA receptor upon glutamate binding and postsynaptic events; Amyotrophic lateral sclerosis (ALS); CREB phosphorylation through the activation of Ras |
Function : | identical protein binding; phospholipase binding; protein C-terminus binding |
◆ Recombinant Protein
Nefl-4363M | Recombinant Mouse Nefl Protein, Myc/DDK-tagged | +Inquiry |
NEFL-1292H | Recombinant Human NEFL Protein, His-SUMO/MYC-tagged | +Inquiry |
NEFL-1472M | Recombinant Mouse NEFL Protein (2-543 aa), His-tagged | +Inquiry |
NEFL-23H | Recombinant Human NEFL Protein, His-tagged | +Inquiry |
NEFL-10563M | Recombinant Mouse Nefl Protein, Myc/DDK-tagged | +Inquiry |
|
◆ Native Protein
NEFL-181B | Native bovine NEFL | +Inquiry |
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◆ Lysates
NEFL-3884HCL | Recombinant Human NEFL 293 Cell Lysate | +Inquiry |
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