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Recombinant Human IL2RA, Fc-tagged

Cat.No.: IL2RA-170H
Product Overview: Recombinant Human IL2RA /CD25 Protein,C-Fc Tag (rh IL2RA /CD25 Fc Chimera) Glu 22 - Cys 213 (Accession # NP_000408) was produced in human 293 cells (HEK293).
Description: Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
Source: HEK293
Species: Human
Tag: Fc
Predicted N Terminal: Glu 22
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: rh IL2RA /CD25 Fc Chimera is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 48.4 Kda. The predicted N-terminus is Glu 22. DTT-reduced Protein migrates as 60-75 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh IL2RA /CD25 Fc Chimera by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Applications: CD Antigens
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: IL2RA interleukin 2 receptor, alpha [ Homo sapiens ]
Official Symbol: IL2RA
Synonyms: IL2RA; interleukin 2 receptor, alpha; IL2R; interleukin-2 receptor subunit alpha; CD25; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha; TCGFR; IDDM10;
Gene ID: 3559
mRNA Refseq: NM_000417
Protein Refseq: NP_000408
MIM: 147730
UniProt ID: P01589
Chromosome Location: 10p15-p14
Pathway: Arf6 trafficking events, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem;
Function: drug binding; interleukin-2 binding; interleukin-2 receptor activity; receptor activity;

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