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Recombinant Mouse Pcsk9, His-tagged, C13&N15 Labeled
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Cat.No. : | Pcsk9-197M |
Product Overview : | Recombinant Mouse PCSK9 MS Standard Protein, C13 and N15-labeled (Mouse PCSK9, Heavy Labeled) Gln 35 - Gln 694 (Accession # AAH38085.1) was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain >99% incorporation |
Description : | Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). |
Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Predicted N Terminal : | Gln 35 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
Molecular Mass : | Mouse PCSK9, Heavy Labeled is fused with polyhistidine tag at the C-terminus, and has a calculated MW of 72 kDa. The predicted N-terminus is Gln 35. DTT-reduced Protein migrates as 20 kDa and 64 kDa in SDS-PAGE due to glycosylation and proteolytic digesti |
Endotoxin : | Less than 1.0 EU per μg of the Mouse PCSK9, Heavy Labeled by the LAL method. |
Purity : | >97% as determined by SDS-PAGE. |
Applications : | MS Standard Protein |
Storage : | Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC). |
Gene Name : | Pcsk9 proprotein convertase subtilisin/kexin type 9 [ Mus musculus ] |
Official Symbol : | Pcsk9 |
Synonyms : | PCSK9; proprotein convertase subtilisin/kexin type 9; NARC-1; convertase subtilisin; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; neural apoptosis-regulated convertase 1; FH3; PC9; Narc1; HCHOLA3; AI415265; AI747682; MGC47409; |
Gene ID : | 100102 |
mRNA Refseq : | NM_153565 |
Protein Refseq : | NP_705793 |
Pathway : | NGF processing, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem; |
Function : | apolipoprotein receptor binding; hydrolase activity; identical protein binding; low-density lipoprotein particle receptor binding; low-density lipoprotein particle receptor binding; peptidase activity; serine-type endopeptidase activity; serine-type endop |
◆ Recombinant Protein
Pcsk9-209M | Recombinant Mouse Pcsk9 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
PCSK9-135H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-692H | Recombinant Human PCSK9 Protein (Met1-Gln692), MIgG1 Fc-tagged | +Inquiry |
PCSK9-035H | Recombinant Human PCSK9 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
PCSK9-040H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
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◆ Lysates
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
PCSK9-2775RCL | Recombinant Rhesus PCSK9 cell lysate | +Inquiry |
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◆ Assay kits
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
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