Recombinant Human ABCB7, GST-tagged ABCB7-23H

Recombinant Human ABCB7, GST-tagged


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Recombinant Human ABCB7, GST-tagged

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Cat.No. : ABCB7-23H
Product Overview : Recombinant Human ABCB7(39 a.a. - 753 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
Description : The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 104.39 kDa
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 [ Homo sapiens ]
Official Symbol : ABCB7
Synonyms : ABCB7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; ABC7; ATP-binding cassette sub-family B member 7, mitochondrial; ASAT; Atm1p; EST140535
Gene ID : 22
mRNA Refseq : NM_004299
Protein Refseq : NP_004290
MIM : 300135
UniProt ID : O75027
Chromosome Location : Xq13.3
Pathway : ABC transporters; ABC-family proteins mediated transport; Cytosolic iron-sulfur cluster assembly
Function : ATP binding; ATPase activity, coupled to transmembrane movement of substances; heme transporter activity

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