Species : |
Human |
Source : |
E.coli |
Tag : |
Flag&His |
Protein Length : |
1310-1430 a.a. |
Description : |
Bromodomain and WD repeat domain containing 1 (BRWD1), also known as WDR9 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. The bromodomain functions as a "reader" of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. In mouse, this BRWD1 is a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain. This domain associates with a component of the SWI/SNF chromatin remodeling complex and may function to regulate chromatin remodeling. BRWD1 plays a role in the regulation of cell morphology and cytoskeletal organization and is also required in the control of cell shape. |
Form : |
25 mM HEPES pH 7.5, 150 mM NaCl and 5% glycerol. |
Molecular Mass : |
18.97 kDa |
Applications : |
Binding assays, inhibitor screening, and selectivity profiling. |
Storage : |
Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
Concentration : |
9 mg/ml |