"ADAM10" Related Products


Recombinant Human ADAM10, His-tagged

Cat.No. : ADAM10-18H
Product Overview : Recombinant Human ADAM10(Thr214-Glu672), fused with a C-terminal 10-His tag, was expressed in Sf 21(baculovirus).
Description : Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
Source : Sf 21 (baculovirus)
Species : Human
Tag : His
Predicted N Terminal : Thr214
Form : Recombinant Human ADAM10 is prone to proteolytic cleavage at C-terminus. The predominant form of the purified protein lacks the His tag. Supplied as a 0.2 µm filtered solution in MES, NaCl, ZnCl2,Glycerol and Brij-35.
Bio-activity : Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2.
Molecular Mass : Predicted Molecular Mass:52 kDaSDS-PAGE:60 kDa, reducing conditions
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 °C as supplied.3 months, -70 °C under sterile conditions after opening.
Gene Name : ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens ]
Official Symbol : ADAM10
Synonyms : ADAM10; ADAM metallopeptidase domain 10; a disintegrin and metalloproteinase domain 10; disintegrin and metalloproteinase domain-containing protein 10; CD156c; HsT18717; kuz; MADM
Gene ID : 102
mRNA Refseq : NM_001110
Protein Refseq : NP_001101
MIM : 602192
UniProt ID : O14672
Chromosome Location : 15q22
Pathway : Activated NOTCH1 Transmits Signal to the Nucleus; Collagen degradation; Constitutive Signaling by NOTCH1 PEST Domain Mutants
Function : SH3 domain binding; endopeptidase activity; metalloendopeptidase activity

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