"ADAM10" Related Products

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Recombinant Human ADAM10, His-tagged

Cat.No.: ADAM10-18H
Product Overview: Recombinant Human ADAM10(Thr214-Glu672), fused with a C-terminal 10-His tag, was expressed in Sf 21(baculovirus).
Description: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.
Source: Sf 21 (baculovirus)
Species: Human
Tag: His
Predicted N Terminal: Thr214
Form: Recombinant Human ADAM10 is prone to proteolytic cleavage at C-terminus. The predominant form of the purified protein lacks the His tag. Supplied as a 0.2 µm filtered solution in MES, NaCl, ZnCl2,Glycerol and Brij-35.
Bio-activity: Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2.
Molecular Mass: Predicted Molecular Mass:52 kDaSDS-PAGE:60 kDa, reducing conditions
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 °C as supplied.3 months, -70 °C under sterile conditions after opening.
Gene Name: ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens ]
Official Symbol: ADAM10
Synonyms: ADAM10; ADAM metallopeptidase domain 10; a disintegrin and metalloproteinase domain 10; disintegrin and metalloproteinase domain-containing protein 10; CD156c; HsT18717; kuz; MADM
Gene ID: 102
mRNA Refseq: NM_001110
Protein Refseq: NP_001101
MIM: 602192
UniProt ID: O14672
Chromosome Location: 15q22
Pathway: Activated NOTCH1 Transmits Signal to the Nucleus; Collagen degradation; Constitutive Signaling by NOTCH1 PEST Domain Mutants
Function: SH3 domain binding; endopeptidase activity; metalloendopeptidase activity

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