"AMACR" Related Products


Recombinant Human AMACR, His-tagged

Cat.No.: AMACR-107H
Product Overview: Recombinant Human AMACR, transcript variant 2, fused with N-terminal HIS, was expressed in E.coli.
Description: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.
Source: E.coli
Species: Human
Tag: His
Molecular Mass: 22 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1 % Sarkosyl.
Gene Name: AMACR alpha-methylacyl-CoA racemase [ Homo sapiens (human) ]
Official Symbol: AMACR
Synonyms: AMACR; RM; RACE; CBAS4; AMACRD; alpha-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; NP_001161067.1; EC; NP_055139.4; NP_976316.1
Gene ID: 23600
mRNA Refseq: NM_203382
Protein Refseq: NP_976316
MIM: 604489
UniProt ID: Q9UHK6
Chromosome Location: 5p13
Pathway: Beta-oxidation of pristanoyl-CoA; Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate; Peroxisomal lipid metabolism
Function: alpha-methylacyl-CoA racemase activity; receptor binding

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