"ARHGDIB" Related Products

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Recombinant Human ARHGDIB, GST-tagged

Cat.No.: ARHGDIB-29H
Product Overview: Recombinant human ARHGDIB protein, fused with GST-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases.
Source: E.Coli.
Species: Human
Tag: GST
Form: Liquid. In phosphate-buffered Saline(pH 7.4) containing 10% glycerol
Molecular Mass: 49.4 kDa (428aa)
Protein length: 1-201aa
AA Sequence: MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERAEISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFKKRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHSLIKYKKTLL GDGPVVTDPK APNVVVTRLT LVCESAPGPI TMDLTGDLEA LKKETIVLKE GSEYRVKIHF KVNRDIVSGL KYVQHTYRTGMTE KAPEPHVEED DDDELDSKLN YKPPPQKSLK ELQEMDKDDEVKVDKATFMV GSYGPRPEEY EFLTPVEEAP KGMLARGTYH NKSFFTDDDK QDHLSWEWNL SIKKEWTE
Purity: > 90% by SDS - PAGE
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 1.0 mg/ml (determined by Bradford assay)
Gene Name: ARHGDIB Rho GDP dissociation inhibitor (GDI) beta [ Homo sapiens (human) ]
Official Symbol: ARHGDIB
Synonyms: ARHGDIB; Rho GDP dissociation inhibitor (GDI) beta; GDIA2, GDID4, RAP1GN1; rho GDP-dissociation inhibitor 2; Ly GDI; RhoGDI2; Rho GDI 2; rho-GDI beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1
Gene ID: 397
mRNA Refseq: NM_001175
Protein Refseq: NP_001166
MIM: 602843
UniProt ID: P52566
Chromosome Location: 12p12.3
Pathway: Caspase cascade in apoptosis; FAS pathway and Stress induction of HSP regulation; Neurotrophin signaling pathway
Function: GTPase activator activity; Rho GDP-dissociation inhibitor activity

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