"CAPN1" Related Products

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Native Porcine Active Porcine Calpain 1

Cat.No.: CAPN1-65P
Description: The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.
Source: Porcine Erythrocytes
Species: Porcine
Form: Liquid
Bio-activity: ≥ 1000 units/mg protein prior to freezing.
Molecular Mass: 110 kDa
Purity: Purity by SDS-PAGE: ≥85%
Usage: For Research Use Only! Not For Use in Humans.
Notes: Centrifuge the vial prior to opening
Storage: -70°C
Storage Buffer: In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
Shipping: Gel pack
Gene Name: calpain 1, (mu/I) large subunit [ Sus scrofa ]
Official Symbol: CAPN1
Synonyms: calpain-1 catalytic subunit; CANP 1; muCANPcalpain mu-type; micromolar-calpain; calpain-1 large subunit; calcium-activated neutral proteinase 1; micromolar calcium-activated neutral protease 1
Gene ID: 397027
mRNA Refseq: NM_213972
Protein Refseq: NP_999137
Chromosome Location: chromosome: 2
Pathway: Alzheimer"s disease, organism-specific biosystem; Alzheimer"s disease, conserved biosystem; Apoptosis, organism-specific biosystem
Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity

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