Native Porcine Active Porcine Calpain 1

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Native Porcine Active Porcine Calpain 1

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Cat.No. : CAPN1-65P
Description : The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.
Source : Porcine Erythrocytes
Species : Porcine
Form : Liquid
Bio-activity : ≥ 1000 units/mg protein prior to freezing.
Molecular Mass : 110 kDa
Purity : Purity by SDS-PAGE: ≥85%
Usage : For Research Use Only! Not For Use in Humans.
Notes : Centrifuge the vial prior to opening
Storage : -70°C
Storage Buffer : In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
Shipping : Gel pack
Gene Name : calpain 1, (mu/I) large subunit [ Sus scrofa ]
Official Symbol : CAPN1
Synonyms : calpain-1 catalytic subunit; CANP 1; muCANPcalpain mu-type; micromolar-calpain; calpain-1 large subunit; calcium-activated neutral proteinase 1; micromolar calcium-activated neutral protease 1
Gene ID : 397027
mRNA Refseq : NM_213972
Protein Refseq : NP_999137
Chromosome Location : chromosome: 2
Pathway : Alzheimer"s disease, organism-specific biosystem; Alzheimer"s disease, conserved biosystem; Apoptosis, organism-specific biosystem
Function : calcium ion binding; calcium-dependent cysteine-type endopeptidase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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