"CAPN1" Related Products


Native Porcine Active Porcine Calpain 1

Cat.No. : CAPN1-65P
Description : The activity of Calpain activity is attributed to two main isoforms: n-calpain and m-calpain, which are ubiquitously, expressed proteases implicated in cellular migration, cell cycle progression, degenerative processes and cell death. These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (n-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4. CAPN1 is a calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of the substrates involved in cytoskeletal remodeling and signal transduction. CAPN1 is activated by micromolar concentrations of calcium and inhibited by calpastatin.
Source : Porcine Erythrocytes
Species : Porcine
Form : Liquid
Bio-activity : ≥ 1000 units/mg protein prior to freezing.
Molecular Mass : 110 kDa
Purity : Purity by SDS-PAGE: ≥85%
Usage : For Research Use Only! Not For Use in Humans.
Notes : Centrifuge the vial prior to opening
Storage : -70°C
Storage Buffer : In 20 mM imidazole-HCl, 5 mM β-mercaptoethanol, 1 mM EDTA, 1 mM EGTA, 30% glycerol, pH 6.8.
Shipping : Gel pack
Gene Name : calpain 1, (mu/I) large subunit [ Sus scrofa ]
Official Symbol : CAPN1
Synonyms : calpain-1 catalytic subunit; CANP 1; muCANPcalpain mu-type; micromolar-calpain; calpain-1 large subunit; calcium-activated neutral proteinase 1; micromolar calcium-activated neutral protease 1
Gene ID : 397027
mRNA Refseq : NM_213972
Protein Refseq : NP_999137
Chromosome Location : chromosome: 2
Pathway : Alzheimer"s disease, organism-specific biosystem; Alzheimer"s disease, conserved biosystem; Apoptosis, organism-specific biosystem
Function : calcium ion binding; calcium-dependent cysteine-type endopeptidase activity

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