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Native Human Bacterial/Permeability-Increasing Protein

Cat.No.: BPI-72H
Description: Bactericidal/permeability increasing protein (BPI) is a 456 residue protein which is part of the innate immune system. BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against Gram-negative bacteria. It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system; however BPI at certain concentrations can prevent this activation. Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
Source: Human Neutrophil
Species: Human
Form: Frozen
Molecular Mass: 55 kDa
Purity: Purity by SDS-PAGE: ≥95%
Usage: For Research Use Only! Not For Use in Humans.
Notes: Centrifuge the vial prior to opening
Storage: -80°C
Storage Buffer: Frozen in 80 mM Citrate Phosphate, pH 5.6, 0.75 M NaCl.
Shipping: Dry Ice
Gene Name: BPI bactericidal/permeability-increasing protein [ Homo sapiens ]
Official Symbol: BPI
Synonyms: BPI; bactericidal/permeability-increasing protein; bactericidal permeability-increasing protein; BPI fold containing family D; member 1; BPIFD1; CAP 57; recombinant BPI holoprotein, rBPI; BPI fold containing family D, member 1; rBPI;
Gene ID: 671
mRNA Refseq: NM_001725
Protein Refseq: NP_001716
MIM: 109195
UniProt ID: P17213
Chromosome Location: 20q11.23
Function: Gram-negative bacterial cell surface binding; lipid binding; lipopolysaccharide binding;

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