Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Native Human Lipoprotein

Cat.No. : LDLR-85H
  • Specification
  • Gene Information
  • Related Products
Description : In a normal fasting individual, low density lipoprotein concentrations range from 2.0 - 3.5 g/L. LDL constitutes 50% of the total lipoprotein mass in plasma and is the major carrier of cholesterol and cholesteryl esters. LDL levels strongly correlate with coronary heart disease.
Source : Human plasma
Species : Human
Form : Liquid
Molecular Mass : 2,300.0 kDa
Purity : Purity by SDS-PAGE: ≥95%; Purity by HPLC: ≥95%
Usage : For Research Use Only! Not For Use in Humans.
Notes : Centrifuge the vial prior to opening
Storage : 4°C
Storage Buffer : 250 μl liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA
Shipping : Gel pack
Gene Name : LDLR low density lipoprotein receptor [ Homo sapiens ]
Official Symbol : LDLR
Synonyms : LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; familial hypercholesterolemia; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; FH; FHC; LDLCQ2;
Gene ID : 3949
mRNA Refseq : NM_000527
Protein Refseq : NP_000518
MIM : 606945
UniProt ID : P01130
Chromosome Location : 19p13.2
Pathway : Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Hepatitis C, organism-specific biosystem;
Function : calcium ion binding; glycoprotein binding; low-density lipoprotein receptor activity; protein binding; receptor activity; very-low-density lipoprotein particle receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there conditions where upregulation of LDLR might be beneficial? 03/17/2022

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications? 09/02/2021

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction? 09/01/2020

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis? 05/27/2020

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions? 02/23/2018

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.

Customer Reviews (3)

Write a review
Reviews
08/11/2020

    The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    10/07/2018

      Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

      03/04/2017

        the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

        Ask a Question for All LDLR Products

        Required fields are marked with *

        My Review for All LDLR Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends