"F2" Related Products

Native Bovine Thrombin

Cat.No.: F2-90B
Description: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.
Source: Bovine plasma
Species: Bovine
Form: Lyophilized
Bio-activity: >1500 units/mg powder.
Molecular Mass: 37 kDa
Purity: Purity by SDS-PAGE: ≥98%
Usage: For Research Use Only! Not For Use in Humans.
Notes: Centrifuge the vial prior to opening
Storage: -20°C
Storage Buffer: Sterile filtered and lyophilized with Mannitol and Sodium Chloride.
Reconstitution: Reconstitute in sterile water (100 U/ml) with 0.9% NaCl. It forms a clear solution.
Shipping: Gel pack
Gene Name: F2 coagulation factor II (thrombin) [ Bos taurus ]
Official Symbol: F2
Synonyms: prothrombin; thrombin
Gene ID: 280685
mRNA Refseq: NM_173877
Protein Refseq: NP_776302
UniProt ID: P00735
Chromosome Location: chromosome: 15
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem
Function: calcium ion binding; fibrinogen binding; receptor binding

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