Native Human Haptoglobin

Cat.No.: HP-200H
Description: An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
Source: Human Plasma
Species: Human
Form: Lyophilized
Molecular Mass: MW: Hp 1-1: 86,000; Hp 2-1: 200,000; Hp 2-2: 400,000
Purity: >=95% by SDS-PAGE
Usage: For research use only
Quality Control Test: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Stability: >1 year
Storage: -20°C
Storage Buffer: Salt-free lyophilized solid. Packaged and sold in 1 mg aliquots.
Gene Name: HP haptoglobin [ Homo sapiens ]
Official Symbol: HP
Synonyms: HP; haptoglobin; zonulin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, beta polypeptide; haptoglobin, alpha polypeptide; BP; HPA1S; HP2ALPHA2; MGC111141;
Gene ID: 3240
mRNA Refseq: NM_001126102
Protein Refseq: NP_001119574
MIM: 140100
UniProt ID: P00738
Chromosome Location: 16q22.2
Pathway: amb2 Integrin signaling, organism-specific biosystem;
Function: catalytic activity; hemoglobin binding; serine-type endopeptidase activity;

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