Active Native Bovine α-Thrombin-DFP
Cat.No. : | F2-275B |
- Specification
- Gene Information
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Description : | Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII. Thrombin has also been reported to activate factor XIII and platelets, and also functions as a vasoconstrictor protein. The procoagulant activity of thrombin is arrested in two ways: 1) inhibition by either heparin cofactor II or the antithrombin III/heparin complex; or 2) complex formation with thrombomodulin. Formation of the thrombin/thrombomodulin complex results in the inability of thrombin to cleave fibrinogen and activate factors V and VIII, but increases the efficiency of thrombin for activation of the anticoagulant, protein C. |
Source : | Plasma |
Species : | Bovine |
Form : | 20 mM Hepes, 150 mM NaCl, pH 7.4 |
Bio-activity : | Fibrinogen clotting or chromogenic assay |
Molecular Mass : | 36700 |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:19.5, Percent carbohydrate: approximately 5%, Structure: two subunits, approximately Mr=6,000 and 31,000 |
Storage : | -80°C |
Gene Name : | F2?coagulation factor II (thrombin) [?Bos taurus?(cattle) ] |
Official Symbol : | F2 |
Synonyms : | prothrombin; thrombin |
Gene ID : | 280685 |
mRNA Refseq : | NM_173877 |
Protein Refseq : | NP_776302 |
UniProt ID : | P00735 |
Chromosome Location : | chromosome: 15 |
Pathway : | Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem |
Function : | calcium ion binding; fibrinogen binding |
Products Types
◆ Recombinant Protein | ||
F2-069H | Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
F2-1450R | Recombinant Rat F2 Protein, His-tagged | +Inquiry |
F2-1356R | Recombinant Rhesus Macaque F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-882H | Recombinant Human F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-789H | Recombinant Human F2 Protein | +Inquiry |
◆ Native Protein | ||
Thrombin-20H | Active Native Pig Thrombin | +Inquiry |
Prothrombin-270B | Active Native Bovine Prothrombin | +Inquiry |
Thrombin-31M | Active Native Mouse Thrombin | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
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