"TNFRSF18" Related Products


Recombinant Human TNFRSF18, Fc-tagged

Cat.No.: TNFRSF18-2086H
Product Overview: Recombinant Human TNFRSF18(aa 26-162), fused at the C-terminus to the Fc portion of human IgG1, was expressed in HEK 293 cells.
Description: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Source: HEK 293 cells
Species: Human
Tag: Fc
Form: Lyophilized. Contains PBS.
Molecular Mass: ~48kDa (SDS-PAGE)
Endotoxin: <0.01EU/μg purified protein (LAL test; Lonza).
Purity: ≥95% (SDS-PAGE)
Stability: Stable for at least 6 months after receipt when stored at -20°C.
Storage: Short Term Storage: +4°CLong Term Storage: -20°CHandling Advice: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
Concentration: 1mg/ml after reconstitution.
Reconstitution: Reconstitute with 50μl sterile water.
Gene Name: TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens (human) ]
Official Symbol: TNFRSF18
Synonyms: Osteostat; TNFSF18; Tumor necrosis factor ligand superfamily member 18; GITRL; TL6; AITRL; hGITRL; MGC138237; AITR ligand; Activation-inducible TNF-related ligand; GITR ligand; Activation-induced TNFR member Ligand; Glucocorticoid-induced TNF-related ligand; Glucocorticoid-induced TNFR-related protein ligand
Gene ID: 8995
mRNA Refseq: NM_005092
Protein Refseq: NP_005083
MIM: 603898
UniProt ID: Q9UNG2
Chromosome Location: 1q23
Pathway: Cytokine-cytokine receptor interaction; Downstream signaling in naive CD8+ T cells
Function: tumor necrosis factor-activated receptor activity

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