Recombinant Human TNFRSF18 protein, Fc-tagged
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
|Product Overview :||Recombinant Human TNFRSF18 (Gln26-Glu161) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||Gln26|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 41.0 kDa. The protein migrates as 45-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Gln26-Glu161|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of TNFRSF18-2086H :||
Human GITR, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Bioactivity-ELISA of TNFRSF18-2086H :||
Immobilized Human GITR, Fc Tag at 2 μg/mL (100 μL/well) can bind Biotinylated Human GITR Ligand, Avitag,Fc Tag with a linear range of 4-63 ng/mL (QC tested).
|Gene Name :||TNFRSF18|
|Official Symbol :||TNFRSF18|
|Synonyms :||TNFRSF18; tumor necrosis factor receptor superfamily, member 18; tumor necrosis factor receptor superfamily member 18; AITR; CD357; GITR; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein; GITR-D|
|Gene ID :||8784|
|mRNA Refseq :||NM_004195|
|Protein Refseq :||NP_004186|
|UniProt ID :||Q9Y5U5|
◆ Recombinant Protein
|TNFRSF18-1019C||Recombinant Cynomolgus TNFRSF18 Protein (Met1-Glu155), His-tagged||+Inquiry|
|TNFRSF18-894M||Recombinant Mouse TNFRSF18 Protein (Met1-His153), MlgG1 Fc-tagged||+Inquiry|
|TNFRSF18-1995H||Recombinant Human TNFRSF18 Protein, MYC/DDK-tagged||+Inquiry|
|TNFRSF18-2091H||Recombinant Human TNFRSF18 Protein, His-Avi-tagged, Biotinylated||+Inquiry|
|TNFRSF18-619H||Recombinant Human TNFRSF18 Protein, Fc-Avi-tagged, Biotinylated||+Inquiry|
|TNFRSF18-1245RCL||Recombinant Rat TNFRSF18 cell lysate||+Inquiry|
|TNFRSF18-1143HCL||Recombinant Human TNFRSF18 cell lysate||+Inquiry|