Recombinant Chicken ANAPC10
Cat.No. : | ANAPC10-1845C |
Product Overview : | Recombinant Chicken ANAPC10 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Chicken |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | ANAPC10 anaphase promoting complex subunit 10 [ Gallus gallus (chicken) ] |
Official Symbol : | ANAPC10 |
Gene ID : | 422461 |
Protein Refseq : | NP_001008467 |
UniProt ID : | Q5ZL04 |
Products Types
◆ Recombinant Protein | ||
ANAPC10-337H | Recombinant Human ANAPC10 Protein, His (Fc)-Avi-tagged | +Inquiry |
ANAPC10-520M | Recombinant Mouse ANAPC10 Protein, His (Fc)-Avi-tagged | +Inquiry |
Anapc10-1619M | Recombinant Mouse Anapc10 Protein, Myc/DDK-tagged | +Inquiry |
ANAPC10-8244Z | Recombinant Zebrafish ANAPC10 | +Inquiry |
ANAPC10-9634H | Recombinant Human ANAPC10, His-tagged | +Inquiry |
◆ Lysates | ||
ANAPC10-8871HCL | Recombinant Human ANAPC10 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionANAPC10 interacts with several other subunits of the APC/C complex, including ANAPC2, ANAPC6, and ANAPC8. It also interacts with additional regulatory proteins such as ANAPC4 and ANAPC11. These interactions are essential for the assembly and activity of the APC/C complex.
ANAPC10 is a highly conserved protein found in virtually all eukaryotic cells, suggesting a fundamental role in cell cycle regulation. Therefore, it is generally expressed in all cell types. However, the expression levels of ANAPC10 may vary depending on the specific tissue or developmental stage.
Deletion or mutation of ANAPC10 can significantly impact the function of the APC/C complex and disrupt cell cycle regulation. This can lead to various cellular abnormalities, including cell cycle arrest, DNA damage accumulation, and chromosome missegregation. Ultimately, it can result in developmental defects, cell death, or the initiation and progression of diseases such as cancer.
Given its critical role in the cell cycle, the APC/C complex, including ANAPC10, has attracted attention as a potential therapeutic target in cancer treatment. Efforts to develop small molecule inhibitors or disruptors of the APC/C complex are currently underway. However, further studies are needed to assess the feasibility and safety of targeting ANAPC10 specifically.
Currently, there is limited information about diseases specifically associated with ANAPC10 mutations. However, various studies have suggested that dysregulation of the APC/C complex, including its subunits like ANAPC10, can contribute to the development and progression of cancer and other diseases. Further research is needed to fully understand the implications of ANAPC10 mutations in specific disorders.
ANAPC10 has been investigated as a potential diagnostic or prognostic marker in certain cancers. Altered expression or mutations in ANAPC10 have been associated with prognosis in colorectal cancer and ovarian cancer. However, further research is required to determine its clinical utility as a reliable marker in disease diagnosis or prognosis.
ANAPC10 does not appear to have any known isoforms or splice variants in humans. It is a highly conserved protein across species, indicating functional and structural importance.
ANAPC10 expression is tightly regulated throughout the cell cycle. Its levels fluctuate during different phases of the cell cycle, being highest in mitosis when the APC/C complex is most active. Regulation of ANAPC10 expression is complex and involves various signaling pathways and transcriptional regulators that respond to changes in cellular conditions and checkpoints.
While ANAPC10 is primarily known for its role in the cell cycle as a subunit of the APC/C complex, emerging research suggests that it may have additional functions beyond cell cycle regulation. Some studies have implicated ANAPC10 in processes such as DNA repair, centrosome duplication, and chromosome stability, indicating its involvement in maintaining genomic integrity.
Currently, there is limited information about the use of ANAPC10 as a biomarker. However, dysregulation of the APC/C complex, including ANAPC10, has been implicated in various types of cancers. Therefore, further research may explore the potential utility of ANAPC10 as a diagnostic or prognostic biomarker in certain malignancies.
Yes, ANAPC10 can be phosphorylated. Phosphorylation is a common post-translational modification that can regulate protein activity, stability, and protein-protein interactions. The specific phosphorylation sites and the role of ANAC10 phosphorylation are still being investigated.
To the best of our knowledge, there are no specific inhibitors or drugs that directly target ANAPC10. However, due to the critical role of the APC/C complex in cell cycle regulation, there is ongoing research and development of compounds that target the APC/C complex as a whole. These compounds aim to disrupt the activity of the APC/C complex, potentially leading to novel cancer therapies.
ANAPC10 and other subunits of the APC/C complex are regulated by multiple mechanisms during the cell cycle. One critical regulation mechanism involves post-translational modifications, such as phosphorylation and ubiquitination, which can affect the stability, activity, and localization of ANAPC10. Additionally, the expression of ANAPC10 can be controlled by various transcription factors and signaling pathways that are activated during different stages of the cell cycle.
ANAPC10 interacts with various proteins to form the APC/C complex. These include other subunits of the APC/C complex such as ANAPC2, ANAPC4, and ANAPC11. Additionally, ANAPC10 can interact with various regulatory proteins and co-factors to ensure proper APC/C function, including APC/C activator proteins such as CDC20 and CDH1.
Dysregulation of the APC/C complex, including ANAPC10, has been implicated in several diseases, particularly in cancer. Mutations or aberrant expression of ANAPC10 and other APC/C subunits have been observed in various malignancies, including colorectal cancer, breast cancer, and ovarian cancer. Additionally, ANAPC10 dysregulation has been linked to developmental disorders and neurodegenerative diseases, although more research is needed to understand these associations fully.
Currently, the primary function of ANAPC10 is associated with the regulation of the cell cycle through the APC/C complex. However, some studies suggest that ANAPC10 may have additional roles in processes such as DNA repair, gene expression, and centrosome replication. Further research is needed to fully understand any potential non-cell cycle-related functions of ANAPC10.
Customer Reviews (5)
Write a reviewThe manufacturer of ANAPC10 protein plays a crucial role in supporting my research efforts.
the manufacturer's commitment to quality control is essential in achieving reliable and consistent outcomes
The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
This guidance allows me to design and implement experiments effectively while adhering to best practices, enhancing the reliability and reproducibility of my results.
They ensure the purity, integrity, and functionality of ANAPC10 protein through rigorous quality control measures.
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