Recombinant Human ADAM 10, His-tagged

• Cat.No.: ADAM10-265H
• Product Overview: RecombinantHuman ADAM 10 comprises a 459 amino acid fragment (214-672) corresponding to the ADAM 10 extracellular domain minus the signal peptide and pro-sequence and is expressed in E. coli with an amino-terminal hexahistidine tag.

Specification

• Cat. No.: ADAM10-265H
• Description: ADAM 10 is a member of the ADAM family of membrane-anchored cell surface proteins, which contain both a disintegrin and a metalloprotease domain. ADAM 10 is expressed in a wide variety of tissues and resides on both the cell surface and within the cytoplasm. ADAM10 has been implicated in proteolytic release of a number of cell surface proteins in particular TNF alpha.
• Source: E.coli.
• Purity: >95% by SDS-PAGE
• Form: Liquid
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: ADAM10 ADAM metallopeptidase domain 10 [ Homo sapiens ]
• Synonyms: ADAM10; CD156c; HsT18717; MADM; kuz; AD10; KUZ; EC 3.4.24.81; A desintegrin and metalloprotease domain 10; Mammalian disintegrin-metalloprotease; Kuzbanian protein homolog; CDw156c antigen; AD10; CDw156; kuzbanian; CD156c antigen; a disintegrin and metalloprotease domain 10; ADAM metallopeptidase domain 10; ADAM10 ADAM metallopeptidase domain 10.
• Gene ID: 102
• mRNA Refseq: NM_001110
• Protein Refseq: NP_001101
• MIM: 602192
• UniProt ID: O14672
• Chromosome Location: 15q2; 15q22
• Pathway: Epithelial cell signaling in Helicobacter pylori infection; Signaling by EGFR; Signaling by Notch
• Function: SH3 domain binding; integrin binding; metal ion binding; metalloendopeptidase activity; peptidase activity; protein homodimerization activity; protein kinase binding; zinc ion binding