Recombinant Chicken ANG4

• Cat.No.: ANG4-3994C
• Product Overview: Recombinant Chicken ANG4 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Chicken
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ANG4 angiogenin 4 [ Gallus gallus (chicken) ]
• Official Symbol: ANG4
• Gene ID: 100302572
• Protein Refseq: NP_001157124
• UniProt ID: C6EX06

Reviews

08/21/2020

The manufacturer can provide researchers with a high-quality, purified form of ANG4 protein, ensuring its integrity and functionality for experimental use.

03/10/2018

In some cases, manufacturers may be open to collaborating with researchers to further investigate the applications and potential of ANG4 protein.

11/17/2016

ANG4 protein may have a specific binding affinity or interaction with its target molecules or receptors, making it a valuable tool for targeted therapies or diagnostic applications.

09/02/2016

This collaboration can involve sharing resources, expertise, and data to advance scientific understanding and therapeutic development.

03/11/2016

If researchers require modifications or specific variants of ANG4 protein for their experiments, the manufacturer could potentially offer custom protein engineering services to meet their needs.

Q&As

How is ANG4 protein involved in neurodegenerative diseases?

Some studies have suggested that ANG4 may play a role in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Mutations in the angiogenin gene, which produces both ANG and ANG4, have been associated with familial ALS. These mutations are thought to impair the angiogenin's neuroprotective functions and lead to motor neuron degeneration. The specific involvement of ANG4 in neurodegenerative diseases requires more investigation.

How is ANG4 detected or measured in research studies?

Currently, there are no widely established methods specifically designed to detect or measure ANG4 protein levels in research studies. However, techniques such as immunohistochemistry, western blotting, and enzyme-linked immunosorbent assays (ELISA) can potentially be used for this purpose with the appropriate antibodies or assays.

Are there any ongoing clinical trials targeting ANG4 protein?

As of now, there are no ongoing clinical trials specifically targeting ANG4 protein. However, research on angiogenin-based therapies, which may indirectly affect ANG4, is ongoing, especially in the context of cancer and neurodegenerative diseases.

Is ANG4 protein being targeted in drug development?

Currently, there are no known drug development efforts specifically targeting ANG4 protein. However, angiogenin-based therapies targeting angiogenesis are being explored for their potential in cancer treatment and tissue regeneration. It is possible that future research may uncover specific applications or inhibitors targeting ANG4 for therapeutic purposes.

Are there any known ANG4 knockout or overexpression studies?

There are no known knockout or overexpression studies specifically focused on ANG4. However, knockout and overexpression studies of other angiogenin family members have been conducted to investigate their biological functions and analyze their effects on various cellular processes.

Are there any known interactions between ANG4 protein and other molecules or proteins?

ANG4 protein has been shown to interact with several molecules and proteins involved in the regulation of angiogenesis, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and matrix metalloproteinases (MMPs). These interactions contribute to the complex process of blood vessel formation.

Is ANG4 protein found in circulation?

ANG4 protein has been detected in the bloodstream, although its levels might be comparatively lower than other angiogenin family members like angiogenin (ANG). The presence of ANG4 in circulation suggests its potential role in systemic angiogenesis regulation, but more research is needed to understand its specific functions and dynamics in different physiological and pathological contexts.

How is the expression of ANG4 protein regulated?

The expression of ANG4 protein is influenced by various factors. It can be upregulated by hypoxia, growth factors like VEGF and FGF, and inflammatory cytokines. Certain transcription factors, such as HIF-1α (hypoxia-inducible factor-1α) and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), can also regulate ANG4 expression. The precise mechanisms behind its regulation are not fully understood and require further investigation.

Are there any diseases or conditions associated with dysregulation of ANG4 protein?

Dysregulation or abnormal expression of ANG4 has been associated with certain cancers, including breast, lung, and cervical cancer. ANG4 may contribute to tumor growth, invasion, and metastasis by promoting angiogenesis.

Can ANG4 protein be used as a therapeutic target or biomarker?

While ANG4 is a relatively less studied member of the angiogenin family, its potential as a therapeutic target or biomarker is not well established. Due to its involvement in angiogenesis and tumor progression, it may have therapeutic implications in cancer treatment. However, further research is required to validate its potential in these areas.

Are there any animal models or knockout studies exploring the role of ANG4 protein?

Currently, there is limited research on ANG4 and its specific role in animal models or knockout studies. Most studies have focused on its closely related family member, angiogenin (ANG), which has been extensively studied for its angiogenic properties and potential therapeutic applications.