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Recombinant Human Complexin 1, His-tagged

Cat.No. : CPLX1-305H
Product Overview : Recombinant Complexin 1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (154 aa, 17.1 kDa).
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Cat. No. : CPLX1-305H
Description : Complexin1 belongs to a family of SNARE complex binding proteins that were suggested to be either facilitators or inhibitors of vesicle exocytosis. Complexin 1 exhibits reduced Ca2+-triggered fast neurotransmitter release at hippocampal glutamatergic synapses, indicating that this protein is a positive regulator of transmitter release. In contrast, it inhibits SNARE-mediated liposome and cell fusions in vitro, which lead to the hypothesis that it acts as fusion clamps of synaptic exocytosis.
Source : E.coli.
Formulation : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Molecular Weight : 17.1 kDa (154 aa) (Real molecular weight on SDS-PAGE will be shift up).
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Endotoxin Level : < 1.0 EU per 1 μg of protein (determined by LAL method).
Sequence : MGSSHHHHHH SSGLVPRGSH MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : CPLX1
Synonyms : CPLX1; complexin 1; CPX1; CPX-I; CPLX1; CPX I; Complexin I; complexin 1 synaphin 2; Synaphin-2.
Gene ID : 10815
mRNA Refseq : NM_006651.3
Protein Refseq : NP_006642.1
MIM : 605032
UniProt ID : O14810
Chromosome Location : 4p16.3
Pathway : Synaptic Transmission.
Function : syntaxin binding.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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