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Recombinant Mouse Il13

Cat.No.: Il13-16M
Product Overview: A DNA sequence encoding the mouse IL13 (Pro22-Phe131) was expressed and purified.
Description: Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.
Source: Human Cells
Species: Mouse
Predicted N Terminal: Pro 22
Form: Lyophilized from sterile PBS, pH 7.5
Bio-activity: Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The ED50 for this effect is typically 2-10 ng/mL.
Molecular Mass: The recombinant mouse IL13 consists of 110 amino acids and predicts a molecular mass of 12.1 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Purity: > 90 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70°C
Storage: Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: Il13 interleukin 13 [ Mus musculus (house mouse) ]
Official Symbol: Il13
Synonyms: Il13; interleukin13; Il-13;interleukin-13;OTTMUSP00000005816; T-cell activation protein P600; IL-13
Gene ID: 16163
mRNA Refseq: NM_008355
Protein Refseq: NP_032381
UniProt ID: P20109
Chromosome Location: 11 B1.3; 11 31.98 cM
Pathway: Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Glucocorticoid receptor regulatory network
Function: cytokine activity; interleukin-13 receptor binding; cytokine receptor binding

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