Native Human GPIIbIIIa

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Native Human GPIIbIIIa

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Cat.No. : ITGA2B-10H
Product Overview : Platelet membrane glycoproteins IIb and IIIa (GPIIb and GPIIIa) constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of 2 disulfide-linked subunits GPIIb (MW = 125,000) and GPII (MW= 23,000) while GPIIIa has only one polypeptide chain (MW= 108,000). GPIIbIIIa migrates on gels as follows: GPIIb 136,000 non-reduced and 125,000 reduced. GPIIIa is 97,000 non-reduced and 108,000 reduced.
Source : Human plasma
Species : Human
Form : liquid
Purity : >95% by SDS-PAGE analysis
Usage : For in vitro laboratory use only
Notes : Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet.
Storage : -20°C
Concentration : 2.0 mg/ml
Storage Buffer : 0.02M Tris-HCl; 0.1M NaCl; 0.1% Triton X-100; 0.001M CaCl2; 0.05% NaN3; 50% glycerol; pH 7.4
Preservative : SodiumAzide
Shipping : Cold pack
Gene Name : ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [ Homo sapiens ]
Official Symbol : ITGA2B
Synonyms : ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); GP2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B); integrin alpha-IIb; CD41; CD41B; GPalpha IIb; platelet-specific antigen BAK; platelet membrane glycoprotein IIb; platelet fibrinogen receptor, alpha subunit; GT; GTA; GP2B; HPA3; GPIIb; BDPLT2;
Gene ID : 3674
mRNA Refseq : NM_000419
Protein Refseq : NP_000410
MIM : 607759
UniProt ID : P08514
Chromosome Location : 17q21.32
Pathway : Arf6 signaling events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;
Function : extracellular matrix binding; identical protein binding; protein binding; receptor activity;

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