Active Recombinant Human CCL3

• Cat.No.: CCL3-15H
• Product Overview: Human recombinant MIP-1 alpha is produced in genetically engineered yeast, and purified by sequential chromatography.

Specification

• Description: Macrophage Inflammatory Protein MIP-1 alpha is part of the CC subfamily of the chemokine superfamily of chemoattractant cytokines. MIP-1 alpha affects the inflammatory response of blood monocytes, tissue macrophages, and T cells. MIP-1 alpha also enhances the formation of granulocyte-macrophage colonies stimulated by GM-CSF or M-CSF. Human MIP-1 alpha is composed of 69 amino acid residues with not possible N-linked glycosylation sites, and several possible O-linked sites. Human MIP-1 alpha is 60% homologous with human MIP-1 alpha, 75% homologous with murine MIP-1 alpha, and has been shown to be active on murine cells.
• Source: yeast
• Species: Human
• Form: In water at a concentration of 1.0 mg protein/ml
• Bio-activity: The biological activity of recombinant human MIP-1 alpha is determined by its use as a cofactor for CSF-dependent myelopoiesis.
• Molecular Mass: 8 KDa
• Purity: Over 95% pure by SDS gel electrophoresis, with low level of endotoxin.
• Stability: Several months at -80°C.
• Storage: Store at -80°C.

Gene Information

• Gene Name: CCL3 chemokine (C-C motif) ligand 3 [ Homo sapiens (human) ]
• Official Symbol: CCL3
• Synonyms: CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha; C-C motif chemokine 3; SIS-beta; PAT 464.1; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha;tonsillar lymphocyte LD78 alpha protein;small inducible cytokine A3 (homologous to mouse Mip-1a)
• Gene ID: 6348
• mRNA Refseq: NM_002983
• Protein Refseq: NP_002974
• MIM: 182283
• UniProt ID: P10147
• Chromosome Location: 17q12
• Pathway: Chagas disease (American trypanosomiasis); Chemokine signaling pathway; Cytokine-cytokine receptor interaction
• Function: CCR1 chemokine receptor binding; calcium-dependent protein kinase C activity; identical protein binding