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Recombinant Human BMPR1B, His-tagged

Cat.No. : BMPR1B-84H
Product Overview : Recombinant human BMPR1B was expressed in E.coli and purified by using conventional chromatography techniques.
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  • Gene Information
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Description : BMPR1B also known as bone morphogenetic protein receptor type-1B isoform b. BMPR1B is on ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. It"s receptor for BMP7/OP-1 and GDF5.
Source : E.coli
Species : Human
Tag : His
Form : Liquid. In Phosphate buffered saline (pH7.4) containing 20% glycerol, 1mM DTT, 0.1mM PMSF
Molecular Mass : 15.1kDa (136aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR
Purity : >80% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5mg/ml (determined by Bradford assay)
Gene Name : BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
Official Symbol : BMPR1B
Synonyms : BMPR1B; bone morphogenetic protein receptor, type IB; bone morphogenetic protein receptor type-1B; ALK6; CDw293; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase; ALK-6;
Gene ID : 658
mRNA Refseq : NM_001203
Protein Refseq : NP_001194
MIM : 603248
UniProt ID : O00238
Chromosome Location : 4q23-q24
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Ovarian Infertility Genes, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;
Function : ATP binding; SMAD binding; activin receptor activity, type II; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can BMPR1B be targeted for regenerative medicine purposes? 02/19/2023

Yes, the role of BMPR1B in tissue regeneration, especially in bone and cartilage, makes it a potential target for regenerative medicine approaches.

In what ways can BMPR1B be targeted for therapeutic purposes? 07/13/2017

Therapeutic strategies may involve the use of small molecules, antibodies, or gene therapies to modulate BMPR1B activity for treating various clinical conditions.

How does BMPR1B protein contribute to fertility in humans? 11/06/2016

BMPR1B is involved in the regulation of ovarian function and follicular development, making it relevant to fertility treatments and reproductive medicine.

How does BMPR1B contribute to the development of the nervous system? 07/25/2016

BMPR1B is involved in neural development, and understanding its role could have implications for neuroregenerative medicine and the treatment of neurodevelopmental disorders.

Is BMPR1B associated with any autoimmune diseases? 02/04/2016

While the direct association with autoimmune diseases is not well-established, the role of BMPR1B in immune regulation might be explored for potential implications in autoimmune disorders.

Customer Reviews (3)

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Reviews
07/24/2021

    Great performance in ELISA.

    02/02/2018

      Researchers can confidently rely on this high-quality protein to produce accurate and reproducible results, thereby accelerating their research progress

      08/15/2017

        Its well-established reputation and reliability further contribute to its suitability for a wide range of experimental designs.

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