Recombinant Human GFRAL protein, His-tagged
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|Product Overview :||Recombinant Human GFRAL (Ser19-Glu351) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).|
|Description :||GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.|
|Predicted N Terminal :||Ser19|
|Form :||Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Ser19-Glu351|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of GFRAL-1493H :||
Human GFR alpha-like, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Gene Name :||GFRAL|
|Official Symbol :||GFRAL|
|Synonyms :||GFRAL; GDNF family receptor alpha like; C6orf144, chromosome 6 open reading frame 144; GDNF family receptor alpha-like; bA360D14.1; GRAL; UNQ9356; IVFI9356; C6orf144|
|Gene ID :||389400|
|mRNA Refseq :||NM_207410|
|Protein Refseq :||NP_997293|
|UniProt ID :||Q6UXV0|
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