Recombinant Human GFRAL protein, His-tagged
Cat.No. : | GFRAL-1493H |
Product Overview : | Recombinant Human GFRAL (Ser19-Glu351) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ser19 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Ser19-Glu351 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | GFRAL |
Official Symbol : | GFRAL |
Synonyms : | GFRAL; GDNF family receptor alpha like; C6orf144, chromosome 6 open reading frame 144; GDNF family receptor alpha-like; bA360D14.1; GRAL; UNQ9356; IVFI9356; C6orf144 |
Gene ID : | 389400 |
mRNA Refseq : | NM_207410 |
Protein Refseq : | NP_997293 |
MIM : | 617837 |
UniProt ID : | Q6UXV0 |
Products Types
◆ Recombinant Protein | ||
GFRAL-22H | Recombinant Human GFRAL Protein, His-tagged | +Inquiry |
GFRAL-6321M | Active Recombinant Mouse Gfral Protein, Fc-tagged | +Inquiry |
GFRAL-1929H | Recombinant Human GFRAL Protein (19-351 aa), His-SUMO-tagged | +Inquiry |
Gfral-264M | Recombinant Mouse Gfral Protein, Gln20-Glu350, N-His-Avi tagged, Biotinylated | +Inquiry |
GFRAL-001H | Recombinant Human GFRAL Protein, 19-351, N-Fc tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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