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Recombinant Human GFRAL protein, His-tagged

Cat.No. : GFRAL-1493H
Product Overview : Recombinant Human GFRAL (Ser19-Glu351) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Ser19
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Ser19-Glu351
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name : GFRAL
Official Symbol : GFRAL
Synonyms : GFRAL; GDNF family receptor alpha like; C6orf144, chromosome 6 open reading frame 144; GDNF family receptor alpha-like; bA360D14.1; GRAL; UNQ9356; IVFI9356; C6orf144
Gene ID : 389400
mRNA Refseq : NM_207410
Protein Refseq : NP_997293
MIM : 617837
UniProt ID : Q6UXV0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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