Active Recombinant Human CRLF2, Fc-tagged

• Cat.No.: CRLF2-76H
• Product Overview: Recombinant Human CRLF2 was expressed in Mouse NSO Cells.

Specification

• Description: This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Fc
• Predicted N Terminal: Gly25
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit TSLP-dependent proliferation of BaF3 mouse pro-B cells co-transfected with human IL-7 R alpha and human TSLP R. The ED50 for this effect is typically 10 - 30 µg/mL in the presence of 0.2 ng/mL of rhTSLP.
• Molecular Mass: Predicted Molecular Mass: 50.6 kDa (monomer)SDS-PAGE: 65-75 kDa, reducing conditions
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 100 µg/mL in sterile PBS.

Gene Information

• Gene Name: CRLF2 cytokine receptor-like factor 2 [ Homo sapiens (human) ]
• Official Symbol: CRLF2
• Synonyms: CRLF2; cytokine receptor-like factor 2; CRL2; TSLPR; IL-XR; TSLP receptor; P2RY8/CRLF2 fusion; cytokine receptor-like 2; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin receptor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; CRLF2Y
• Gene ID: 64109
• mRNA Refseq: NM_022148
• Protein Refseq: NP_071431
• MIM: 300357
• UniProt ID: Q9HC73
• Chromosome Location: Xp22.3; Yp11.3
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; TSLP Signaling Pathway