"DCK" Related Products

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Recombinant Human DCK, His-tagged

Cat.No.: DCK-796H
Product Overview: Recombinant Human DCK, fused with N-terminal polyhistidine tag, was expressed in Sf9 cells.
Description: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Source: Sf9 cells
Species: Human
Tag: His
Molecular Mass: 30 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Storage Buffer: 50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Gene Name: DCK deoxycytidine kinase [ Homo sapiens (human) ]
Official Symbol: DCK
Synonyms: DCK; deoxycytidine kinase; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119; EC 2.7.1.74
Gene ID: 1633
mRNA Refseq: NM_000788
Protein Refseq: NP_000779
MIM: 125450
UniProt ID: P27707
Chromosome Location: 4q13.3-q21.1
Pathway: Purine metabolism; Pyrimidine metabolism
Function: ATP binding; deoxycytidine kinase activity; kinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; transferase activity

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