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Recombinant Human TDO2, MYC/DDK-tagged

Cat.No.: TDO2-824H
Product Overview: Recombinant Human TDO2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description: This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Bio-activity: The specific activity of TDO2 was determined by monitoring Kynurenine formation from the N-formylkynurenine based on the absorbance at 492nm.
Molecular Mass: 47.7 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens (human) ]
Official Symbol: TDO2
Synonyms: TDO; TPH2; TRPO; TDO2; tryptophan 2,3-dioxygenase; TO; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase; EC 1.13.11.11
Gene ID: 6999
mRNA Refseq: NM_005651
Protein Refseq: NP_005642
MIM: 191070
UniProt ID: P48775
Chromosome Location: 4q31-q32
Pathway: Metabolic pathways; Tryptophan metabolism; Metabolism of amino acids and derivatives
Function: amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; oxygen binding; tryptopha 2,3-dioxygenase activity

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