Recombinant Human TDO2, MYC/DDK-tagged TDO2-824H

Recombinant Human TDO2, MYC/DDK-tagged

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Recombinant Human TDO2, MYC/DDK-tagged

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Cat.No. : TDO2-824H
Product Overview : Recombinant Human TDO2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description : This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Bio-activity : The specific activity of TDO2 was determined by monitoring Kynurenine formation from the N-formylkynurenine based on the absorbance at 492nm.
Molecular Mass : 47.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens (human) ]
Official Symbol : TDO2
Synonyms : TDO; TPH2; TRPO; TDO2; tryptophan 2,3-dioxygenase; TO; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase; EC 1.13.11.11
Gene ID : 6999
mRNA Refseq : NM_005651
Protein Refseq : NP_005642
MIM : 191070
UniProt ID : P48775
Chromosome Location : 4q31-q32
Pathway : Metabolic pathways; Tryptophan metabolism; Metabolism of amino acids and derivatives
Function : amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; oxygen binding; tryptopha 2,3-dioxygenase activity

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