Recombinant Human CRY2, MYC/DDK-tagged CRY2-1159H

Recombinant Human CRY2, MYC/DDK-tagged


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Recombinant Human CRY2, MYC/DDK-tagged

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Cat.No. : CRY2-1159H
Product Overview : Recombinant Human CRY2, transcript variant 1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.
Description : This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene.
Source : HEK293 cells
Species : Human
Molecular Mass : 66.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : CRY2 cryptochrome circadian clock 2 [ Homo sapiens (human) ]
Official Symbol : CRY2
Synonyms : CRY2; cryptochrome 2 (photolyase-like); cryptochrome-2; growth-inhibiting protein 37; HCRY2; PHLL2; FLJ10332; KIAA0658; cryptochrome circadian clock 2
Gene ID : 1408
mRNA Refseq : NM_021117
Protein Refseq : NP_066940
MIM : 603732
UniProt ID : Q49AN0
Chromosome Location : 11p11.2
Pathway : BMAL1:CLOCK,NPAS2 activates circadian gene expression; Circadian Clock; Circadian rhythm; Diurnally regulated genes with circadian orthologs
Function : NOT DNA (6-4) photolyase activity; DNA binding; blue light photoreceptor activity

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