Active Recombinant Human CD86, Fc Chimera
Cat.No. : | CD86-204H |
Product Overview : | Recombinant Human CD86 (Accession # AAB03814) was produced in Mouse myeloma cell line, NS0-derived. |
- Specification
- Gene Information
- Related Products
- Download
Source : | Mammalian cells |
Species : | Human |
Tag : | Fc Chimera |
Predicted N Terminal : | Leu20 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. |
Bio-activity : | Measured by its ability to induce IL-2 secretion by Jurkat human acute T cell leukemia cells. Freeman, G.J. et al. (1993) Science 262:909.The ED50 for this effect is typically 0.2-0.8 µg/mL in the presence of PHA. |
Molecular Mass : | Recombinant Human CD86, Fc Chimera has a calculated MW of 52.7 kDa (monomer). In SDS-PAGE migrates as 85-95 kDa, reducing conditions. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | CD86 CD86 molecule [ Homo sapiens ] |
Official Symbol : | CD86 |
Synonyms : | CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413; |
Gene ID : | 942 |
mRNA Refseq : | NM_001206924 |
Protein Refseq : | NP_001193853 |
MIM : | 601020 |
UniProt ID : | P42081 |
Chromosome Location : | 3q21 |
Products Types
◆ Recombinant Protein | ||
CD86-596M | Recombinant Mouse CD86 Protein | +Inquiry |
Cd86-10R | Recombinant Rat Cd86 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD86-1095H | Recombinant Human CD86 Protein (Met1-His239), HlgG1 Fc-tagged | +Inquiry |
CD86-1289C | Recombinant Cynomolgus/Rhesus CD86 protein(Met1-His239), hFc-tagged | +Inquiry |
Cd86-40M | Recombinant Mouse CD86 Protein (ECD), His-tagged(C-ter) | +Inquiry |
◆ Lysates | ||
CD86-2598MCL | Recombinant Mouse CD86 cell lysate | +Inquiry |
CD86-1013CCL | Recombinant Cynomolgus CD86 cell lysate | +Inquiry |
CD86-2619HCL | Recombinant Human CD86 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.
In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.
CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.
There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.
CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.
Customer Reviews (3)
Write a reviewWith the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.
The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.
Ask a Question for All CD86 Products
Required fields are marked with *
My Review for All CD86 Products
Required fields are marked with *
Inquiry Basket