"RIPK2" Related Products

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Recombinant Human RIPK2, MYC/DDK-tagged

Cat.No.: RIPK2-532H
Product Overview: Recombinant human RIPK2 fused with MYC/DDK tag at C-terminal, was expressed in HEK293 cells.
Description: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
Source: HEK293 cells
Species: Human
Tag: MYC/DDK
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 61 kDa
Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: RIPK2 receptor-interacting serine-threonine kinase 2 [ Homo sapiens ]
Official Symbol: RIPK2
Synonyms: RIPK2; receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30
Gene ID: 8767
mRNA Refseq: NM_003821
Protein Refseq: NP_003812
MIM: 603455
UniProt ID: O43353
Chromosome Location: 8q21
Pathway: Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem;
Function: ATP binding; CARD domain binding; CARD domain binding; LIM domain binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; signal transducer activity;

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