Recombinant Human MAP2K1, His-tagged

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Recombinant Human MAP2K1, His-tagged

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Cat.No. : MAP2K1-2568H
Product Overview : Recombinant human mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1) produced in Sf9 cells is a single polypeptide chain with a 6His tag at the N-terminus. It contains 405 (12+393) amino acids, and having a predicted molecular mass of approximately 44.7kD, but migrates in SDS-PAGE with an apparent molecular mass of 50kD.
Description : The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Source : Baculovirus
Species : Human
Tag : His
Form : 20mM Tris-Cl (pH7.9), 20% Glycerol, 100mM NaCl, 1mM DTT and 0.5mM EDTA
Bio-activity : In addition to being a member of the dual specificity protein kinase family, MAP2K1 also acts as an integration point for multiple biochemical signals in signal tansduction pathway. Recombinant human MAP2K1 (or MEK1) protein is ideal for the studies of protein phosphorylation and other related function assays.
AA Sequence : MAHHHHHHAS GGMPKKKPTP IQLNPAPDGS AVNGTSSAET NLEALQKKLE ELELDEQQRK RLEAFLTQKQ KVGELKDDDF EKISELGAGN GGVVFKVSHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS MGLSLVEMAV GRYPIPPPDA KELELMFGCQ VEGDAAETPP RPRTPGRPLS SYGMDSRPPM AIFELLDYIV NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH AFIKRSDAEE VDFAGWLCST IGLNQPSTPT HAAGV
Purity : ≥90%, as determined by SDS-PAGE
Usage : FOR RESEARCH ONLY
Storage : The protein sample can be stored under sterile conditions at 2- 8 centigrade for one month or at -70 centigrade for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Gene Name : MAP2K1 mitogen-activated protein kinase kinase 1 [ Homo sapiens ]
Official Symbol : MAP2K1
Synonyms : CFC3; MEK1; MKK1; MAPKK1; PRKMK1; dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Gene ID : 5604
mRNA Refseq : NM_002755
Protein Refseq : NP_002746
MIM : 176872
UniProt ID : Q02750
Chromosome Location : 15q22.1-q22.33
Pathway : AGE/RAGE pathway, organism-specific biosystem; ARMS-mediated activation, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem
Function : ATP binding; MAP kinase kinase activity; Ras GTPase binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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