Active Recombinant Human MYC, His-tagged

• Cat.No.: MYC-2522H
• Product Overview: Recombinant human myc proto-oncogene protein produced in E.coli is a single non-glycosylated polypeptide with a 8His tag at the C-terminus. It contains 452 (442+10) amino acids having a predicted molecular mass of approximately 50.4kD, but migrates in SDS-PAGE with an apparent molecular mass of 60kD.

Specification

• Description: Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 20mM Tris-Cl (pH7.9), 20% Glycerol, 100mM NaCl, 1mM DTT and 0.5mM EDTA
• Bio-activity: c-Myc protein is a multi-functional protein involved in cell cycle progression, apoptosis, cellular transformation and transcriptional regulation. Recombinant c-Myc protein is ideal for the studies of protein-protein interactions and other related function assays.
• AA Sequence: MASMPLNVSFTNRNYDLDYDSVQPY FYCDEEENFYQQQQQSELQPPAPSE DIWKKFELLPTPPLSPSRRSGLCS PSYVAVTPFSLRGDNDGGGGSFSTA DQLEMVTELLGGDMVNQSFICDPDD ETFIKNIIIQDCMWSGFSAAAKLV SEKLASYQAARKDSGSPNPARGHSV CSTSSLYLQDLSAAASECIDPSVVF PYPLNDSSSPKSCASQDSSAFSP SSDSLLSSTESSPQGSPEPLVLHEE TPPTTSSDSEEEQEDEEEIDVVSVE KRQAPGKRSESGSPSAGGHSKPPH SPLVLKRCHVSTHQHNYAAPPSTRK DYPAAKRVKLDSVRVLRQISNNRKC TSPRSSDTEENVKRRTHNVLERQ RRNELKRSFFALRDQIPELENNEKA PKVVILKKATAYILSVQAEEQKLIS EEDLLRKRREQLKHKLEQLRNSCA LEHHHHHHHH
• Purity: ≥90%, as determined by SDS-PAGE
• Usage: FOR RESEARCH ONLY
• Storage: The protein sample can be stored under sterile conditions at 2- 8 centigrade for one month or at -70 centigrade for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: MYC v-myc avian myelocytomatosis viral oncogene homolog [ Homo sapiens ]
• Official Symbol: MYC
• Synonyms: MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; avian myelocytomatosis viral oncogene homolog; class E basic helix-loop-helix protein 39; myc-related translation/localization regulatory factor; proto-oncogene c-Myc; transcription factor p64; v-myc myelocytomatosis viral oncogene homolog
• Gene ID: 4609
• mRNA Refseq: NM_002467
• Protein Refseq: NP_002458
• MIM: 190080
• UniProt ID: P01106
• Chromosome Location: 8q24.21
• Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Apoptosis, organism-specific biosystem
• Function: DNA binding; E-box binding; protein binding