Active Recombinant Human IFNG
Cat.No. : | IFNG-1367H |
Product Overview : | Recombinant human IFN-γ produced in E. coli. is a non-covalent Dimer non-glycosylated, containing 140 amino acids, and having a molecular mass of approximately 16.5kDa. |
- Specification
- Gene Information
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Description : | Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation. IFN-γ exerts its biological activities by binding to specific cell surface receptors with high-affinity binding sites. The IFN-γ receptor is present on almost all cell types except mature erythrocytes and has been cloned and characterized. The IFN-γ receptor is structurally related to the recently cloned IL-10 receptor. |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered solution in 20mM Phosphate buffer |
Bio-activity : | Bioactivity is detected using WISH cell (a heteroploid human amnion cell line). The specific activity shall be not less than 2.0×10^7 IU/mg of protein. |
Endotoxin : | ≤1EU/μg, determined by the LAL method. |
Purity : | ≥97%, as determined by SDS-PAGE and HPLC method. |
Usage : | FOR RESEARCH ONLY |
Storage : | Lyophilized samples are stable for greater than six months from date of receipt at -20 centigrade to -70 centigrade. The reconstituted samples can be stored under sterile conditions at 2-8 centigrade for one month or at -20 centigrade to -70 centigrade for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile ddH2O containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of not less than 10μg/ml of the cytokine. |
Gene Name : | IFNG interferon, gamma [ Homo sapiens ] |
Official Symbol : | IFNG |
Synonyms : | IFG; IFI |
Gene ID : | 3458 |
mRNA Refseq : | NM_000619 |
Protein Refseq : | NP_000610 |
MIM : | 147570 |
UniProt ID : | P01579 |
Chromosome Location : | 12q14 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Allograft Rejection, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem |
Function : | cytokine activity; interferon-gamma receptor binding |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIFNG plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
The development of drugs for IFNG is currently in clinical trials, including monoclonal antibodies against IFNG receptors and inhibitors against IFNG signaling pathways.
Studies have shown that IFNG can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.
In clinical practice, the expression level of IFNG can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen.
Yes, there are other coding variants in the IFNG gene that may have different functions and expression patterns.
Such as nutritional status, inflammation levels, etc. Yes, the expression of IFNG is affected by environmental factors, such as nutritional status, inflammation level, etc.
Customer Reviews (3)
Write a reviewIt is analyzed by X-ray crystallography or other crystallization techniques and has good crystallization properties.
Easy to attach to the surface of cells or materials.
IFNG products have a complete range of specifications for experimental designs of different sizes and needs.
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