"CD274" Related Products

Recombinant Human CD274, mouse IgG1-Fc-tagged

Cat.No.: CD274-2146H
Product Overview: Recombinant Human CD274(Phe 19 - Thr 238) fused with C-terminal mouse IgG1-Fc tag, was expressed in HEK293 cells.
Description: Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
Source: HEK293 cells
Species: Human
Tag: Fc
Predicted N Terminal: Phe 19
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Has a calculated MW of 51.6 kDa, DTT-reduced Protein migrates as 65-85 kDa in SDS-PAGE due to glycosylation.
Endotoxin: Less than 1.0 EU per μg of the rh PDL1 /CD274, C-mFc Tag by the LAL method.
Purity: >92% as determined by SDS-PAGE.
Usage: For Research Use Only
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Gene Name: CD274 CD274 molecule [ Homo sapiens ]
Official Symbol: CD274
Synonyms: B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1
Gene ID: 29126
mRNA Refseq: NM_001267706
Protein Refseq: NP_001254635
MIM: 605402
UniProt ID: Q9NZQ7
Chromosome Location: 9p24
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem
Function: protein binding

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