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Active Recombinant Mouse Agrp

Cat.No. : Agrp-588M
Product Overview : Recombinant Mouse Agrp (Accession # NP_031453) Ser82-Thr131, fused with , was produced in E. coli.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Mouse
Predicted N Terminal : Ser82
Form : Lyophilized from a 0.2 µm filtered solution in PBS.
Bio-activity : Measured by its ability to antagonize alpha -MSH-induced cAMP accumulation in HEK293 human embryonic kidney cells transfected with human Melanocortin-4 Receptor. Ollmann, M.M. et al. (1997) Science 278:135.The ED50 for this effect is typically 0.025-0.15 µg/mL in the presence of 10 ng/mL of alpha -MSH.
Molecular Mass : Recombinant Mouse Agrp has a calculated MW of 5.7 kDa.
Protein length : Ser82-Thr131
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Gene Name : Agrp agouti related protein [ Mus musculus ]
Official Symbol : Agrp
Synonyms : AGRP; agouti related protein; agouti-related protein; orexigenic neuropeptide; Art; Agrt;
Gene ID : 11604
mRNA Refseq : NM_007427
Protein Refseq : NP_031453
MIM :

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can AGRP be targeted for the treatment of obesity? 03/30/2022

AGRP and the melanocortin system are potential targets for developing anti-obesity therapies, and research is ongoing to develop selective agonists or antagonists to modulate AGRP signaling.

Is AGRP involved in other physiological processes besides appetite regulation? 03/04/2022

AGRP is also implicated in the modulation of autonomic functions, such as blood pressure regulation and cardiovascular control.

What are the downstream signaling pathways activated by AGRP? 03/02/2020

AGRP inhibits the signaling of melanocortin receptors, leading to reduced cAMP production and affecting intracellular pathways involved in appetite and energy regulation.

How is AGRP involved in the central regulation of energy balance? 02/24/2020

AGRP acts as a key neuropeptide in the hypothalamus, integrating signals from peripheral tissues to regulate energy homeostasis, appetite, and body weight.

What is the relationship between AGRP and the melanocortin system? 11/03/2019

AGRP functions as an antagonist to melanocortin receptors, counteracting the effects of α-melanocyte-stimulating hormone (α-MSH), which promotes satiety and energy expenditure.

Can AGRP interact with other neuropeptides in appetite regulation? 10/10/2019

Yes, AGRP can interact with other neuropeptides, such as neuropeptide Y (NPY), and together they influence the central regulation of appetite and energy balance.

Can alterations in AGRP expression contribute to eating disorders? 07/06/2019

Dysregulation of AGRP expression or activity has been suggested to contribute to the development of certain eating disorders, such as binge eating disorder or hyperphagia.

Can AGRP be used as a diagnostic marker for metabolic disorders? 05/27/2019

While AGRP itself is not typically used as a diagnostic marker, studying its expression levels or genetic variations may provide insights into the risk and development of metabolic disorders.

How does AGRP regulate appetite? 07/23/2018

AGRP acts on the melanocortin receptors in the brain, inhibiting their activation and resulting in an increase in appetite and a decrease in energy expenditure.

Can AGRP be used as a biomarker for monitoring the efficacy of weight loss interventions? 05/11/2018

AGRP levels may have potential as a biomarker for monitoring the response to weight loss interventions, but further research is needed to establish its clinical utility.

Customer Reviews (5)

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Reviews
09/21/2019

    This company offers a wide range of recombinant proteins at competitive prices.

    08/08/2019

      The pricing structure for their proteins is transparent and reasonable.

      07/04/2019

        The customer support team was extremely helpful and responsive, providing detailed information about the products.

        05/09/2018

          We are exceedingly satisfied with the quality of this protein.

          03/14/2018

            The exceptional quality of the proteins makes it a great value for the cost.

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